丁健

职称：副教授

学历/学位：研究生、博士

电话：0510－85326276

电子邮箱：dingjian@jiangnan.edu.cn

简介

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主要从事发酵工程、发酵过程优化、智能工程和自动控制等领域的研究，主要承担《发酵过程优化与控制》、《生化工程》等课程讲授工作。近年来共发表研究论文10余篇；申请发明专利6项，其中授权3项，软件著作权2项；主持包括国家自然科学基金（青年）在内的科研项目4项。

学习工作经历

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2002-2006西北农林科技大学,生物技术专业,理学学士

2007-2009江南大学，发酵工程专业，工学硕士

2009-2014江南大学，发酵工程专业，工学博士

2014-2017江南大学，生物工程学院，讲师

2016-至今 江南大学，物联网工程学院，博士后

2017-至今 江南大学，生物工程学院，副教授

主要成果

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一、论文（论著）发表情况

1、Jia L-Q, Shi Z-P, Yan J, Ding J, Hua Q. Enhancing heterologous proteins production by MutS Pichia pastoris via periodic methanol induction control[J]. AIChE Journal,2020,66(1).

2、Ding J, Xu M, Xie F, Chen C, Shi Z-P*. Efficient butanol production using corn-starch and waste Pichia pastoris semi-solid mixture as the substrate, Biochemical Engineering Journal, 2019.春季, 143: 41~47.

3、Ding J, Luo H-Z, Xie F, Wang H, Xu M;Shi Z-P*. Electron receptor addition enhances butanol synthesis in ABE fermentation by Clostridium acetobutylicum, Bioresource Technology, 2018, 247: 1201~1205.

4、Jia L-Q, Gao M-J, Yan J, Chen S-S, Sun J-W, Huai Q, Ding J*, Shi Z-P*. Evaluation of the sub-optimalinduction strategies for heterologous proteins production by Pichia pastoris Mut+/MutS strains and related transcriptional and metabolic analysis, World Journal of Microbiology and Biotechnology, 2018.冬季, 34.

5、Jia L-Q, Enock Mpofu, Tu T-Y,Huai Q-Q, Sun J-W,Chen S-S,Ding J*,Shi Z-P*.Transcriptional analysis for carbon metabolism and kinetic modeling for heterologous proteins productions by Pichia pastoris in induction process with methanol/sorbitol co-feeding, Process Biochemistry, 2017, 59: 159~166.

6、Ding J,Tu T-Y, Huai Q-Q,Sun J-W, Chen S-S, Li X, Shi Z-P*,Ding J*. Enhancing monellin production by Pichia pastoris at low cell induction concentration via effectively regulating methanol metabolism patterns and energy utilization efficiency , Plos One, 2017, 12(10).

7、Ding, J, Enock Mpofu, Gao M-J*, Ren X-D*. An on-line adaptive glucose feeding system incorporating patterns recognition for glucose concentration control in glutamate fermentations , Biotechnology and Bioprocess Engineering, 2016, 21(6): 758~766.

8、Ding J*, Gao M-J, Hou G-L, Liang K-X. Effect of ethanol accumulation on porcine interferon-αproduction by Pichia pastoris and activities of key enzymes in carbon metabolism, Applied Biochemistry and Biotechnology, 2015, 176: 1964~1974.

9、Ding J*, Wang H-H, Dai K-K, Zi Y-H,Shi Z-P. Prediction of porcine interferonαantiviral activity in fermentation by Pichia pastoris based on multivariable regression and artificial neural network, Chemical Industry & Chemical Engineering Quarterly, 2014.春季, 20(1): 29~38.

10、Ding J, Zhang C-L*, Gao M-J, Hou G-L, Liang K-X, Li C-H, Ni J-P,Li Z,Shi Z-P. Enhanced porcine circovirus Cap protein production by Pichia pastoris with a fuzzy logic DO control based methanol/sorbitol co-feeding induction strategy , Journal of Biotechnology, 2014.5.10, 177: 35~44.

11、Ding J, Gao M-J, Hou G-L, Liang K-X, Yu Y-S, Li Z,Shi Z-P*. Stabilizing porcine interferon-αproduction by Pichia pastoris with an ethanol on-line measurement based DO-Stat glycerol feeding strategy, Journal of Chemical Technology and Biotechnology, 2014.秋季, 89: 1948~1953.

12、Ding J, Cao Y, Enock Mpofu,Shi Z-P*. A hybrid support vector machine and fuzzy reasoning based fault diagnosis and rescue system for stable glutamate fermentation, Chemical Engineering Research and Design, 2012 .9, 90(9): 1197~1207.

二、专利情况

1、丁健，张许.一种基于差分进化算法的酵母培养在线自适应控制方法.专利号：201510689736，2015-10-21

2、于瑞嵩，史仲平，高敏杰，丁健，董世娟，朱于敏.一种应用重组毕赤酵母稳定地生产猪α干扰素的方法.专利号：201310488705.8，2013-10-17

3、史仲平，丁健，王浩，罗洪镇，陈锐，何珍妮.一种自由控制丙丁梭菌ABE发酵丙酮生产产量与丙酮/丁酸比的方法.专利号：201610037929.0，2019-3-19

三、软件著作权情况

1、丁健;陈祖华;张劲楠;朱容辰,“百仑慧神”数据采集软件,2019SR0014092,原始取得,全部权利, 2018.6.10

2、丁健;陈祖华;张劲楠;朱容辰,“百仑慧神”数据分析软件,2019SR0014083,

原始取得,全部权利, 2018.1.10

四、承担教学科研项目情况

1、江苏省自然科学基金青年项目，Mut^S和Mut⁺型重组毕赤酵母表达外源蛋白关键因素的转录组学分析和优化控制

2、国家博士后基金项目，毕赤酵母对诱导条件的响应机理及其诱导过程的优化控制

3.国家自然科学基金青年项目，甲醇/山梨醇共混诱导条件下，毕赤酵母高效表达外源蛋白的转录组学机理及在线最优化控制研究。

4.企业合作项目，“百仑慧神”发酵数据采集/分析软件的开发

以上资料更新时间截止：2020年4月