徐沙
徐沙
职称：副教授、硕士生导师
学历/学位：研究生、博士
电话：15061867809
电子邮箱：xusha1984@jiangnan.edu.cn
长期从事微生物代谢工程的研究，主要承担代谢途径工程、发酵工程原理与技术课程的讲授工作。近年来共发表高水平研究论文20余篇，主持包括国家科学基金等在内的省部级科研项目5项。
2017.10 – 至今: 副教授，江南大学，粮食发酵与食品生物制造国家工程研究中心
2015.10 – 2017.10: 副教授，江南大学，生物工程学院，糖化学与生物技术教育部重点实验室
2011.08 – 2015.10: 讲师，江南大学，生物工程学院，糖化学与生物技术教育部重点实验室
2016.08 - 2017.08： 访问学者，美国康奈尔大学，分子生物学与遗传学学院，合作导师：Prof.YuxinMao
2013.11 – 2014.02： 访问学者，日本产业综合研究所(AIST)
2012.01 – 2012.02： 访问学者，日本产业综合研究所(AIST)
2006.09 – 2011.06:江南大学，博士，发酵工程，导师：陈坚教授
2002.09 – 2006.06:南京农业大学，学士，生物工程
一、论文（论著）发表情况
部分代表性论文如下：
1.Sha Xu, Guangjian Li, Jingwen Zhou, Guicai Chen*, Jianzhong Shao*. Efficient production of anthocyanins inSaccharomyces cerevisiaeby introducing anthocyanin transporter and knocking out endogenous degrading enzymes. Front Bioeng Biotechnol, 2022, 10: 899182.
2.Sha Xu, Qin Wang, Weizhu Zeng, Youran Li, Guiyang Shi, Jingwen Zhou*. Construction of a heat-inducible Escherichia coli strain for efficient de novo biosynthesis of L-tyrosine, Process Biochem, 2020, 92: 85-92.
3.Sha Xu, Yu Zhang, Youran Li, Xiaole Xia, Jingwen Zhou*, Guiyang Shi*. Production of L-tyrosine using tyrosine phenol-lyase by whole cell biotransformation approach. Enzyme Microb. Tech. 2019, 131, 109430
4.Yongkun Lv,Sha Xu, Yunbin Lyu, Shenghu Zhou, Guocheng Du, Jian Chen, Jingwen Zhou*. Engineering enzymatic cascades for the efficient biotransformation of eugenol and taxifolin to silybin and isosilybin. Green Chem. 2019, 21(7):1660-1667.
5.Wang Panpan, Zeng Weizhu,Xu Sha, Du Guocheng, Zhou Jingwen*, Chen Jian*. Current challenges facing one-step production of l-ascorbic acid. Biotechnol Adv. 2018, 36(7): 1882-1899.
6.Huijie Zhang, Ting Yan,Sha Xu, Shini Feng, Dandi Huang, Morihisa Fujita, Xiaodong Gao*. Graphene oxide-chitosan nanocomposites for intracellular delivery of immunostimulatory CpG oligodeoxynucleotides. Mater Sci Eng C Mater Biol Appl. 2017, 73:144-151.
7.Weizhu Zeng, Hailin Zhang,Sha Xu, Fang Fang, Jingwen Zhou*. Biosynthesis of keto acids by fed-batch culture ofYarrowia lipolyticaWSH-Z06. Bioresour Technol. 2017, 243:1037-1043.
8.Sha Xu, Geyuan Zhang, Huijie Zhang, Toshihiko Kitajima, Hideki Nakanishi, Xiaodong Gao*. Effects of Rho1, a small GTPase on the production of recombinant glycoproteins inSaccharomyces cerevisiae. Microb Cell Fact. 2016, 15 (1):179.
9.Shengtao Li, Ning Wang,Sha Xu, Jian Yin, Hideki Nakanishi, Neta Dean, Xiaodong Gao*. Quantitative study of yeast Alg1 beta-1,4 mannosyltransferase activity, a key enzyme involved in proteinN-glycosylation. Biochim Biophys Acta 1861. 2016 (1 Pt A):2934-2941.
10.Yu Deng, Mingxue Sun,Sha Xu, Jingwen Zhou*. Enhanced (S)-linalool production by fusion expression of farnesyl diphosphate synthase and linalool synthase inSaccharomyces cerevisiae. J Appl Microbiol. 2016, doi:10.1111/jam.13105.
11.Jingwen Zhou*, Kui Wang,Sha Xu, Junjun Wu, Peiran Liu, Guocheng Du, Jianghua Li*, Jian Chen. Identification of membrane proteins associated with phenylpropanoids tolerance and transport inEscherichia coliBL21. J Proteomics. 2015, 113: 15-28.
12.Sha Xu, Xiaobei Wang, Guocheng Du, Jingwen Zhou*, Jian Chen. Enhanced production of L-sorbose from D-sorbitol by improving the mRNA abundance of sorbitol dehydrogenase inGluconobacter oxydansWSH-003. Microb Cell Fact. 2014, 13:146.
13.Sha Xu, Yaqiong Guo, Guocheng Du, Jingwen Zhou*, Jian Chen. Self-cloning significantly enhances the production of catalase inBacillus subtilisWSHDZ-01. Appl Biochem Biotechnol. 2014, 173(8): 2152-62.
14.Sha Xu, Zhengxiong Zhou, Zhaozhe Hua, Guocheng Du, Jingwen Zhou*, Jian Chen. Efficient transformation ofRhizopus delemarby electroporation of germinated spores. J Microbiol Meth. 2014. 103: 58-63.
15.Sha Xu, Jingwen Zhou, Liming Liu*, Jian Chen* Arginine: a novel compatible solute to protectCandida glabrataagainst hyperosmotic stress. Proc Biochem. 2011, 44(6): 1230-1235.
16.Yi Qin, Liming Liu, Changhao Li,Sha Xu, and Jian Chen*. Accelerating glycolytic flux ofTorulopsis glabrataCCTCC M202019 at high oxiodreduction potential created using potassium ferricyanide. Biotechnol Prog, 2010, 26(6): 1551-1557.
17.Sha Xu, Jingwen Zhou, Liming Liu*, Jian Chen*. Water-forming NADH oxidase protectsTorulopsis glabrataagainst hyperosmotic stress. Yeast. 2010, 27(4): 207-216.
18.Sha Xu, Jingwen Zhou, Liming Liu*, Jian Chen*. Proline enhancesTorulopsis glabratagrowth during hyperosmotic stress. Biotechnol Bioproc Eng. 2010, 15(2): 285-292.
19.周亲亲，徐沙，周景文*.番茄红素合成基因组合优化和产物测定[J].食品与发酵工业, 2020, 46(18): 24-32.
20.孙玲，李由然，张梁，丁重阳，顾正华，石贵阳，徐沙*．高效合成番茄红素酿酒酵母菌株的构建.生物工程学. 2020, 36(7): 1-12.
21.焦亭亭,周景文,徐沙*.柚皮素合成关键基因表达水平对目标产物积累水平的量化影响.生物工程学报. 2019, 35(7): 1256-1265.
22.董宁远,张阁元,徐沙,高晓冬*.来源于胞曲霉的α-1,2-甘露糖苷酶在酿酒酵母Δalg3Δoch1Δmnn1菌株中的定位表达.食品与发酵工业. 2016, 42 (6):1-6.
23.张阁元,徐沙,高晓冬*,中西秀树.酿酒酵母糖基化缺陷型菌株中ALG6基因的过量表达.食品与发酵工业. 2015, 41 (5):1-7.
24.贺铁凡,徐沙,张阁元,中西秀树,高晓冬*.重构酿酒酵母N-糖基化途径生产人源化糖蛋白.微生物学报. 2014, 54 (5):509-516.
25.徐沙,中西秀树,高晓冬*.糖蛋白药物表达系统糖基化研究进展.微生物学报. 2013, 53 (3):221-229
专利：
1.堵国成,徐沙,刘立明,陈坚.一种添加脯氨酸促进丙酮酸过量积累的方法.公开号：101225410.
2.陈坚,徐沙,刘立明,堵国成.一种提高光滑球拟酵母抵御高渗透压胁迫的方法.公开号：101591670
二、承担教学科研项目情况
1.国家自然基金青年项目“超糖基化缺陷型酿酒酵母生产人源化糖蛋白N-聚糖位点占有率定向调控”(21406087),主持
2.江南大学自主科研计划项目基金“重组酿酒酵母产人促红细胞生成素糖基化机制的研究”，(JUSRP211A25),主持
3.工业生物技术教育部重点实验室开放课题“Alg1结构与膜结合性质的研究”(KLIB-KF201106),主持
以上资料更新时间截止：2022年9月
