田光宗

职称：助理研究员

学历/学位：研究生/博士

电话：0510-85197039

电子邮箱：guangzong.tian@jiangnan.edu.cn

简介

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主要从事糖化学、糖生物学等领域的研究，特别是针对致病菌细胞表面复杂糖链的全合成及其免疫学进行研究，主要承担《糖生物工程》、《糖化学》课程的讲授工作。近年来以第一作者身份在J. Am. Chem. Soc.、Angew. Chem. Int. Ed.、Org. Lett.、Chem. Commun.、Chinese J. Chem. 等国际权威期刊发表SCI论文11篇；申请中国发明专利3件，授权1件；主持国家自然科学基金青年基金项目1项、国家重点研发计划专项项目子课题1项、中国博士后基金面上项目1项。2020年荣获江南大学“校长特别奖”；2020获江南大学优秀博士论文。

学习工作经历

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2020-07至今,江南大学,生物工程学院,助理研究员

2015-09至2020-06,江南大学,制糖工程,博士

2017-03至2019-05, Max Planck Institute of Colloids and Interfaces,糖化学,联合培养博士

2012-09至2015-06,江南大学,制糖工程,硕士

2008-09至2012-06,山东农业大学,食品科学与工程,学士

主要成果

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一、论文（论著）发表情况

部分代表性论文如下：

1.Guangzong Tian; Jing Hu; Chunjun Qin; Lingxin Li; Yunzhan Ning; Shengyong, Zhu; Sunqing Xie; Xiaopeng Zou; Peter H. Seeberger; Jian Yin; Chemical synthesis and antigenicity evaluation of an aminoglycoside trisaccharide repeating unit ofPseudomonas aeruginosaserotype O5 O‑antigen containing a rare dimeric-ManpN₃NA,Journal of the American Chemical Society, 2024, 146(27), 18427-18439.

2.Guangzong Tian; Jing Hu; Chunjun Qin; Lingxin Li; Xiaopeng Zou; Juntao Cai; Peter H. Seeberger; Jian Yin; Chemical synthesis and immunological evaluation ofHelicobacter pyloriserotype O6 tridecasaccharide O-antigen containing aDD-heptoglycan,Angewandte Chemie International Edition, 2020, 59(32): 13362-13370.

3.Guangzong Tian; Chunjun Qin; Zhonghua Liu; Dacheng Shen; Xiaopeng Zou; Junjie Fu; Jing Hu; Peter H. Seeberger; Jian Yin; Total synthesis of theHelicobacter pyloriserotype O2 O-antigen α-(1→2)- and α-(1→3)-linked oligoglucosides,Chemical Communications, 2020, 56(3): 344-347.

4.Guangzong Tian; Jing Hu; Hengxi Zhang; Christoph Rademacher; Xiaopeng Zou; Hongning Zheng; Fei Xu; Xiaoli Wang; Torsten Linker; Jian Yin; Synthesis and conformational analysis of linear homo- and heterooligomers from novel 2-C-branched sugar amino acids (SAAs),Scientific Reports, 2018, 8(1): 6625.

5.Guangzong Tian; Xiaoli Wang; Jing Hu; Xuebin Wang; Xiaoqiang Guo; Jian Yin; Recent progress of sugar amino acids: Synthetic strategies and applications as glycomimetics and peptidomimetics,Chinese Chemical Letters, 2015, 26(8): 922-930.

6.Guangzong Tian, Chunjun Qin, Jing Hu, Xiaopeng Zou; Jian Yin; Effect of side-chain functional groups in the immunogenicity of bacterial surface glycans,Molecules2023, 28: 7112.

7. Wenbin Sun^#;Guangzong Tian^#; Meiru Ding; Xiaopeng Zou; Jing Hu; Jian Yin; Chemical synthesis of the trisaccharide repeating unit of the O‑antigen ofFusobacterium nucleatumATCC 51191,Organic Letters, 2024, 26: 321−326.

8. Wenbin Sun^#;Guangzong Tian^#; Meiru Ding; Chunjun Qin; Xiaopeng Zou; Jing Hu; Jian Yin; Chemical synthesis of a key precursor relevant to the tetrasaccharide repeating unit fromTreponema mediumATCC 700293,Chinese Journal of Chemistry, 2024, 42, 1615-1622.

9. Ming Zhao^#;Guangzong Tian^#; Chunjun Qin; Xiaopeng Zou; Peter H. Seeberger; Jing Hu; Jian Yin; Immunological exploration ofHelicobacter pyloriserotype O2 O-antigen by using a synthetic glycan library,Chinese Journal of Chemistry, 2024, 42; 243-251.

10. Chunjun Qin^#; Lingxin Li^#;Guangzong Tian^#; Meiru Ding; Shengyong Zhu; Wuqiong Song; Jing Hu; Peter H. Seeberger; Jian Yin; Chemical synthesis and antigenicity evaluation of Shigella dysenteriae serotype 10 O‑antigen tetrasaccharide containing a (S)‑4,6‑O‑pyruvyl ketal,Journal of the American Chemical Society, 2022, 144(46): 21068-21079.

11. Hongli Hou^#;Guangzong Tian^#; Junjie Fu; Chunjun Qin; Guodong Chen; Xiaopeng Zou; Jing Hu; Jian Yin; Highly stereoselective construction of 1,2-cis-D-quinovosamine glycosides for the synthesis ofPseudomonas aeruginosaO-antigen disaccharide,Journal of Carbohydrate Chemistry, 2022, 41(2-3): 155-180.

12. Chunjun Qin; Meiru Ding;Guangzong Tian; Xiaopeng Zou; Junjie Fu; Jing Hu; Jian Yin; Chemical approaches towards installation of rare functional groups in bacterial surface glycans,Chinese Journal of Natural Medicines, 2022, 20(6): 401-420.

13. Xiaopeng Zou; Jing Hu; Ming Zhao; Chunjun Qin; Yuntao Zhu;Guangzong Tian; Juntao Cai; Peter H. Seeberger; Jian Yin; Chemical synthesis of the highly sterically hindered core undecasaccharide ofHelicobacter pylorilipopolysaccharide for antigenicity evaluation with human serum,Journal of the American Chemical Society, 2022, 144(32): 14535-14547.

14. Chunjun Qin; Hongli Hou; Meiru Ding; Yikuan Qi;Guangzong Tian; Xiaopeng Zou; Junjie Fu; Jing Hu; Jian Yin; Chemical synthesis of a synthetically useful L-galactosaminuronic acid building block,Chinese Journal of Natural Medicines, 2022, 20(5): 387-392.

15. Chunjun Qin; Jing Hu; Wei Tong; Tengteng Zhang;Guangzong Tian; Xiaopeng Zou; Jiankai Liu; Jian Yin; Determination of ribose and phosphorus contents in Haemophilus influenzae type b capsular polysaccharide by a quantitative NMR method using a single internal standard,Chinese Journal of Natural Medicines, 2022, 20(8): 633-640.

16. Juntao Cai, Jing Hu, Chunjun Qin, Lingxin Li, Dacheng Shen,Guangzong Tian, Xiaopeng Zou, Peter H. Seeberger, and Jian Yin. Chemical synthesis elucidates the key antigenic epitope of the autism-related bacteriumClostridium bolteaecapsular octadecasaccharide.Angewandte Chemie International Edition, 2020, 59(46): 20529-20537.

17. Xiaopeng Zou; Chunjun Qin; Jing Hu; Junjie Fu;Guangzong Tian; Oren Moscovitz; Peter H. Seeberger; Jian Yin; Total synthesis of D-glycero-D-mannno-heptose 1β,7-bisphosphate with 3-O-amyl amine linker and its monophosphate derivative,Chinese Journal of Natural Medicines, 2020, 18(8): 628-632.

18. Chunjun Qin, Benjamin Schumann, Xiaopeng Zou, Claney L. Pereira,Guangzong Tian, Jing Hu, Peter H. Seeberger, and Jian Yin, Total synthesis of a densely functionalizedPlesiomonas shigelloidesserotype 51 aminoglycoside trisaccharide antigen,Journal of the American Chemical Society, 2018, 140(8): 3120-3127.

19. Xiaopeng Zou, Chunjun Qin, Claney L. Pereira,Guangzong Tian, Jing Hu, Peter H. Seeberger, and Jian Yin. Synergistic glycosylation as key to the chemical synthesis of an outer core octasaccharide ofHelicobacter pylori.Chemistry-A European Journal, 2018, 24(12): 2868-2872.

20.王兆亚;王晓丽;田光宗;尹健;新型葡萄糖型-寡聚糖氨基酸的合成,食品与发酵工业, 2016, 42(12): 68-72.

二、专利情况

1.尹健;胡静;田光宗;一种幽门螺旋杆菌O:6血清型O-抗原糖链的合成方法, 2019-3-1,中国, ZL201910156533.1。

2.尹健;胡静;田光宗; Synthesis method of Helicobacter pylori O:6 serotype O-antigen sugar chain, 2019-6-14, WIPO, PCT/CN2019/091198。

3.胡静;尹健;田光宗;糖氨基酸及利用糖氨基酸制备的寡糖模拟物, 2018-4-9,中国, 201810311402.1。

三、承担教学科研项目情况

1.国家自然科学基金委员会，青年科学基金项目，22107037，2022-01-01至2024-12-31，在研，主持。

2.中国科学技术部，国家重点研发计划专项项目子课题，2023YFC2308000，2023-12至2026-11，在研，主持

3.中国博士后科学基金会，中国博士后科学基金面上项目，2021M691279，2021-01至2022-12，结题，主持。

4.江南大学生物工程学院，“青年人才托举工程”项目，2022至2024，在研，主持.

5.糖化学与生物技术教育部重点实验室开放课题，KLCCB-KF202202，在研，主持。

6.江南大学基本科研计划青年基金项目，JUSRP121012，结题，主持。

四、获奖情况

1. 2021年6月-指导学生荣获第七届江南大学“互联网+”创新创业大赛二等奖；

2.2020年6月-获江南大学校长特别奖；

3.2017年6月-获国家公派出国留学奖学金。

以上资料更新时间截止：2024年10月