1.项目负责人,细胞外小囊泡中微小RNA在乳腺癌化疗耐药中的作用机制研究及相关耐药生物标志物的探索,国家自然科学基金31550006,2015年应急项目。
2.项目负责人,微小RNA表达的甲基化调控对瞬时受体电位通道C5介导的肿瘤多药耐药的影响机制研究,国家自然科学基金31371317,2014年面上项目。
3.项目负责人,细胞膜蛋白TRPC1介导HSV-1病毒感染宿主细胞的作用及机制研究,国家自然科学基金31200126,2012年青年项目。
4.项目负责人,食源皂甙的内生菌转化机制研究,教育部高校自主科研计划JUSRP51615B,2016年重点项目。
5.项目负责人,微小RNA及其甲基化调控对上皮细胞间充质转化通路介导的肿瘤多药耐药的影响机制研究,江苏省自然科学基金BK20141109,2014年面上项目。
代表性学术成果(论文、专利等):
(1) D, He, Q Pan, C Sun, Z Chen, P Zhang, A Mao, Y Zhu, H Li, C Lu, M Xie, Y Zhou, D Shen, C Tang, Z Yang, J Jin, X Yao, B Nilius , X Ma, Treatment of hypertension by augmenting impaired endothelial TRPV4-KCa2.3 coupling. EMBO Molecular Medicine.(2017)9,1491-1503
(2) D.X He, X Ma, Clinical utility of letrozole in the treatment of breast cancer: a Chinese perspective. OncoTargets and Therapy 2016:9 1–8(特邀综述)
(3) D.X. He, F. Gu, F. Gao, J.J. Hao, D. Gong, X.T. Gu, A.Q. Mao, J. Jin, L. Fu, X. Ma, Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer, Scientific Report, 6 (2016) 24706.
(4) D.X. He, F. Gu, J. Wu, X.T. Gu, C.X. Lu, A.Q. Mao, G.Y. Zhang, Z.Y. Ding, J.K. Wang, J.J. Hao, L. Fu, X. Ma, Targeting PSG1 to enhance chemotherapeutic efficacy: new application for anti-coagulant the dicumarol, Clinical Science, 130 (2016) 2267-2276.
(5) D.X. He, G.Y. Zhang, X.T. Gu, A.Q. Mao, C.X. Lu, J. Jin, D.Q. Liu, X. Ma, Genome-wide profiling of long non-coding RNA expression patterns in anthracycline-resistant breast cancer cells, International Journal of Oncology, 49 (2016) 1695-1703.
(6) P. Zhang, D. He (并列第一), Z. Chen, Q. Pan, F. Du, X. Zang, Y. Wang, C. Tang, H. Li, H. Lu, X. Yao, J. Jin, X. Ma, Chemotherapy enhances tumor vascularization via Notch signaling-mediated formation of tumor-derived endothelium in breast cancer, Biochemical Pharmacology , 118 (2016) 18-30
(7) DX He, Xin Ma, Transient receptor potential channel C5 in cancer chemoresistance, Acta Pharmacologica Sinica (2015) 36: 1–6(特邀综述)
(8) Dong-xu He,Guo-Hong Li,Xiao-Ting Gu,Liang Zhang,Ai-Qin Mao,Juan Wei,De-Quan Liu,Gui-Yang Shi,Xin Ma,A new agent developed by biotransformation of polyphyllin VII inhibits chemoresistance in breastcancer,Oncotarget,DOI: 10.18632/oncotarget.6674
(9) Ma, Xin,Chen, Zhen,Hua, Dong,He, Dongxu(并列第一),Wang, Linjun,Zhang, Peng,Wang, Junqi,Cai, Yanfei,Gao, Caiji,Zhang,Xiaodong,Zhang, Fangfang,Wang, Teng,Hong, Tingting,Jin, Linfang,Qi,Xiaowei,Chen, Shuxian,Gu, Xiaoting,Yang, Dangtong,Pan, Qiongxi,Zhu,Yifei,Chen, Yun,Chen, Daozhen,Jiang, Liwen,Han, Xiaofeng,Zhang,Yanyun,Jin, Jian(*),Yao, Xiaoqiang,Essential role for TrpC5-containing extracellular vesicles in breast cancer with chemotherapeutic resistance,PNAS,2014,111(17):6389-6394。
(10) Ma, Xin,Cai, Yanfei,Zou, Chang,Zhang, Peng,Lo,He, Dongxu(并列第一)Chun Yin,Xu, Zhenyu,Chan, Franky L.,Yu, Shan,Chen, Yun,Zhu, Ruiyu,Lei,Jianyong,Jin, Jian(*),Yao, Xiaoqiang(*),Transient receptor potential channel TRPC5 is essential for P-glycoprotein induction in drug-resistant cancer cells,PNAS,2012,109(40):16282-16287。
(11) He, Dongxu,Ru, Xiaochen,Wen, Lei,Wen, Yuechun,Jiang, Huidi,Bruce, Iain C.,Jin, Jian,Ma, Xin(*),Xia, Qiang(*),Total flavonoids of Flos Chrysanthemi protect arterial endothelial cells against oxidative stress,Journal of Ethnopharmacology,2012,139(1):68-73。
(13) Dong-Xu He,Yu-Dong Xia,Xiao-Ting Gu,Jian Jin,Xin Ma,A transcription/translation-based gene signature predicts resistance to chemotherapy in breast cancer,Journal of Pharmaceutical and Biomedical Analysis,2015,102(c):500-508。
(14) Dong-Xu He,Xiao-Ting Gu,Li Jiang,Jian Jin,Xin Ma,A Methylation-based Regulatory Network for microRNA 320a in Chemoresistant Breast Cancer,Molecular Pharmacology,2014,86(5):536-547。
(15) Dong-Xu He,Xiao-Ting Gu,You-Ran Li,Li Jiang,Jian Jin,Xin Ma,Methylation-regulated miRNA-149 modulates chemoresistance by targeting NDST1 in human breast cancer,FEBS Journal,2014,281(20):4718-4730。
(16) Dong-Xu He,Yu-Dong Xia,Xiao-Ting Gu,Ai-Qin Mao,Jian Jin,Xin Ma(*),A 20-gene signature in predicting the chemoresistance of breast cancer to taxane-based chemotherapy,Molecular Biosystems,2014,10(12):3111-3119。
(17) Dongxu He,Jian Jin,Yongtang Zheng,Iain C. Bruce,Siucheung Tam,Xin Ma(*),Anti-angiogenesis effect of trichosanthin and the underlying mechanism,Biochemical and Biophysical Research Communications,2013,430(2):735-740。
(18) X Ma, DX He(并列第一,通讯), XC Ru, Y Chen, YF Cai, IC Bruce, Q Xia, XQ Yao, and J Jin. Apigenin, a plant-derived flavone, activates transient receptor potential TRPV4 cation channel. British Journal of Pharmacology. 2012, 166(1):349-58.
(19) He, Dongxu,Ma, Xin,Chen, Yun,Cai, Yanfei,Ru, Xiaochen,Bruce, Iain C.,Xia, Qiang,Shi, Guiyang(*),Jin, Jian(*),Luteolin inhibits pyrogallol-induced apoptosis through the extracellular signal-regulated kinase signaling pathway,FEBS Journal,2012,279(10):1834-1843。
专利
1.石贵阳,刘双平,李由然,丁红辉,孙秀英,李赢,张梁,丁重阳,何冬旭,顾正华,一种以L-苯丙氨酸为氨基供体的L-苯甘氨酸转氨酶及其应用2015.8.5-2035.5.28,中国,CN201510284722.9。
2.金坚,马鑫,陈蕴,蔡燕飞,何冬旭,阻断型抗体T5E3在逆转肿瘤多药耐药中的
应用,中国,2012103183876。
3.金坚,马鑫,陈蕴,蔡燕飞,何冬旭,TRPC5作为药物靶点在逆转肿瘤多药耐药中的应用,中国,2012103183895。
4.金坚,马鑫,陈蕴,何冬旭,蔡燕飞,转录因子NFATC3作为药物靶点在逆转肿瘤
多药耐药中的应用,中国,2012103183880。
著作
陈金中,高燕宁,郭凌晨,何冬旭,李成涛,秦义龙,汪旭,王然,王凯兵,王明伟,王瑧瑧,夏传武,薛京伦,周彩红,朱焕章,医学分子遗传学(第四版),科学出版社,2013(排名不分先后)