发表论文

发表论文

序号	论文题目	刊物名称	年卷期页	作者全名
1.	Transforming Flask Reaction into Cell-Based Synthesis: Production of Polyhydroxylated Molecules via EngineeredEscherichia coli	Acs Catalysis	2015, 5, 4060-4065	Mohui Wei; Zijie Li; Tiehai Li; Baolin Wu; Yunpeng Liu; Jingyao Qu; Xu Li; Lei Li; Li Cai, and George Wang Peng
2.	Metabolic engineering in the biotechnological production of organic acids in the tricarboxylic acid cycle of microorganisms: Advances and prospects.	Biotechnology Advances	2015，33, 830-841	Xian Yin; Jianghua Li; Shin Hyun-dong; Guocheng Du; Long Liu, and Chen Jian
3.	An optimal glucose feeding strategy integrated with step-wise regulation of the dissolved oxygen level improves N-acetylglucosamine production in recombinantBacillus subtilis	Bioresource Technology	2015，177, 387-392	Yanqiu Zhu; Yan Feng Liu; Jianghua Li; Shin Hyun-dong; Guoche ng Du; Long Liu, and Chen Jian
4.	Post-Golgi anterograde transport requires GARP-dependent endosome-to-TGN retrograde transport	Molecular Biology of the Cell	2015，26, 3071-3084	Tetsuya Hirata; Morihisa Fujita; Shota Nakamura; Kazuyoshi Gotoh; Daisuke Motooka; Murakami Yoshiko; Maeda Yusuke, and Taroh. Kinoshita
5.	Ganglioside-magnetosome complex formation enhances uptake of gangliosides by cells	International Journal of Nanomedicine	2015，10, 6919-6930	Feng Guan; Xiang Li; Jia Guo, and Yang Ganglong
6.	Polyethyleneimine-functionalized boron nitride nanospheres as efficient carriers for enhancing the immunostimulatory effect of CpG oligodeoxynucleotides	International Journal of Nanomedicine	2015，10, 5343-5353	Huijie Zhang; Shini Feng; Ting Yan; Chunyi Zhi, Xiao-DongGao; Hanagata, Nobutaka
7.	Quantitative glycome analysis of N-glycan patterns in bladder cancer vs normal bladder cells using an integrated strategy	Journal of Proteome Research	2015，14, 639-653	Ganglong Yang; Zengqi Tan; Wei Lu; Jia Guo; Hanjie Yu; Jingmin Yu; Chengwen Sun; Xiaowei Qi; Zheng Li, and Feng Guan
8.	Effects of culture conditions on monosaccharide composition ofGanoderma lucidumexopolysaccharide and on activities of related enzymes	Carbohydrate Polymers	2015，133, 104-109	Lin Peng; Shuangkui Qiao; Zhenghong Xu; Feng Guan; Zhongyang Ding; Zhenghua Gu; Liang Zhang, and Shi Guiyang
9.	Significant emission enhancement of a bola-amphiphile with salicylaldehyde azine moiety induced by the formation of pseudorotaxane with gamma-cyclodextrin	Rsc Advances	2015，5, 88176-88180	Jialong Xu; Ying Quan; Qiuyan Li; Han Lu; Hui Wu; Jian Yin; Xiaojun Wang, and Zhang Quan
10.	Engineering propionibacteria as versatile cell factories for the production of industrially important chemicals: advances, challenges, and prospects	Applied Microbiology and Biotechnology	2015，99, 585-600	Ningzi Guan; Xin Zhuge; Jianghua Li; Shin Hyu-ndong; Jing Wu; Zhongping Shi, and Liu Long
11.	Toward metabolic engineering in the context of system biology and synthetic biology: advances and prospects	Applied Microbiology and Biotechnology	2015，99, 1109-1118	Yanfeng Liu; Shin Hyun-dong; Jianghua Li, and Liu Long
12.	Promotion of cell migration by neural cell adhesion molecule (NCAM) is enhanced by PSA in a polysialyltransferase-specific manner	Plos One	2015，10, e0124237	Feng Guan; Xin Wang, and He Fa
13.	Genome-wide screening of genes required for glycosylphosphatidylinositol biosynthesis	Plos One	2015，10, e0138553	Yao Rong; Shota Nakamura; Tetsuya Hirata; Daisuke Motooka; Yishi Liu; Zeng-an He; Xiao-Dong Gao; Yusuke Maeda; Taroh Kinoshita, and Fujita Morihisa
14.	Quantitative analysis of differential proteome expression in bladder cancer vs. normal bladder cells using SILAC method	Plos One	2015，10,e0134727	Ganglong Yang; Zhipeng Xu; Wei Lu; Xiang Li; Chengwen Sun; Jia Guo; Peng Xue, and Feng Guan
15.	Yeast cell-based analysis of human lactate dehydrogenase isoforms	Journal of Biochemistry	2015，158, 467-476	Lulu Ahmed Mohamed; Hiroyuki Tachikawa; Xiao-Dong Gao, and Nakanishi Hideki
16.	Quantitative analysis of glycans, related genes, and proteins in two human bone marrow stromal cell lines using an integrated strategy	Experimental Hematology	2015，43, 760-769	Xiang Li; Dongliang Li; Xingchen Pang; Ganglong Yang; H. Joachim Deeg, and Feng Guan
17.	Identification and functional characterization of intracellular sialidase NeuA3 fromStreptomyces avermitilis	Process Biochemistry	2015，50, 752-758	Jia Guo; Yicheng Wang; Bo Song; Xin Wang; Ganglong Yang, and Feng Guan
18.	Model-based estimation of optimal dissolved oxygen profile inAgrobacterium sp.fed-batch fermentation for improvement of curdlan production under nitrogen-limited condition	Biochemical Engineering Journal	2015，103, 12-21	Hong-Tao Zhang; Li Zhu; Dengfeng Liu; Xiaobei Zhan; Jian Ding; Chichung Lin
19.	Bioconversion of D-glucose to d-psicose with immobilized D-xylose isomerase and D-psicose 3-epimerase onSaccharomyces cerevisiaespores	Journal of Industrial Microbiology & Biotechnology	2015，42, 1117-1128	Zijie Li; Yi Li; Shenglin Duan; Jia Liu; Peng Yuan; Nakanishi Hideki, and Xiao-DongGao
20.	Characterization of glycerol phosphate oxidase fromStreptococcus pneumoniaeand its application for ketose synthesis	Bioorganic & Medicinal ChemistryLetters	2015，25, 504-507	Zijie Li; Yingxin Qiao; Li Cai; Nakanishi Hideki, and Xiao-Dong Gao
21.	Enzymatic synthesis of rare sugars with l-rhamnulose-1-phosphate aldolase fromThermotoga maritimaMSB8	Bioorganic & Medicinal Chemistry Letters	2015，25, 3980-3983	Zijie Li; Xiaoru Wu; Li Cai; Shenglin Duan; Jia Liu; Peng Yuan; Nakanishi Hideki, and Xiao-DongGao
22.	Enhanced expression of polysialic acid correlates with malignant phenotype in breast cancer cell lines and clinical tissue samples	International Journal of Molecular Medicine	2015，doi: 10.3892/ijmm.2015.2395	Xin Wang; Xiang Li; Ying-Nan Zeng; Fa He; Xiaomin Yang, and Feng Guan
23.	A lectin-based isolation/enrichment strategy for improved coverage of N-glycan analysis	Carbohydrate Research	2015，416, 7-13	Feng Guan; Zengqi Tan; Xiang Li; Xingchen Pang; Yunlin Zhu; Dongliang Li, and Yang Ganglong
24.	Identification and characterization of transcriptional control region of the human beta 1,4-mannosyltransferase gene	Cytotechnology	2015，In press DOI: 10.1007/s10616-015-9929-y	Takahashi Tetsuo, Nedachi Takahashi, Etoh Takuya, Tachikawa Hiroyuki, Xiao-Dong Gao
25.	Iron overload induced by ferric ammonium citrate triggers reactive oxygen species-mediated apoptosis via both extrinsic and intrinsic pathways in human hepatic cells	Human & Experimental Toxicology	2015，doi:10.1177/0960327115597312	Shiwei Li; Changmei Liu; Jia Guo; Marcondes AM; Deeg J.; Xiang Li, and Feng Guan
26.	Significantly improving the yield of recombinant proteins inBacillus subtilisby a novel powerful mutagenesis tool (ARTP): Alkaline α-amylase as a case study	Protein Expression and Purification	2015，114, 82-88	Yingfang Ma; Haiquan Yang; Xianzhong Chen; Bo Sun; Guocheng Du; Zhemin Zhou; Jiangning Song; You Fan; Wei Shen
27.	Recent progress of sugar amino acids: Synthetic strategies and applications as glycomimetics and peptidomimetics	Chinese Chemical Letters	2015，26, 922-930	Guangzong Tian; Xiaoli Wang; Jing Hu; Xuebin Wang; Xiaoqiang Guo, and Yin Jian
28.	Downregulation of gangliotetraosylceramide and beta 1,3-galactosyltransferase-4 gene expression by Smads during transforming growth factor beta-induced epithelial-mesenchymal transition	Molecular Medicine Reports	2015，11, 2241-2247	Jia Guo; Bo Song; Xiang Li; Chenhui He; Ganglong Yang, and Feng Guan
29.	Proteomic analysis of erythritol-producingYarrowia lipolyticafrom glycerol in response to osmotic pressure	Journal of Microbiology and Biotechnology	2015，25, 1056-1069	Libo Yang; Xiaomeng Dai; Zhiyong Zheng; Li Zhu; Xiaobei Zhan; Chichung Lin
30.	Study on the synthesis of novel sugar amino acids	Acta Chimica Sinica	2015，73, 699-704	Xuebin Wang; Xiaoli Wang; Jing Hu; Zhaoya Wang; Pimpalpalle Tukaram M; Linker Torsten, and Yin Jian
31.	Synthesis of D-Sorbose and D-Psicose by RecombinantEscherichia coli	Journal of Carbohydrate Chemistry	2015，34, 349-357	Zijie Li; Beibei He; Yahui Gao, and Cai Li
32.	Synthesis and characterization of polysialic acid/carboxymethyl chitosan hydrogel with potential for drug delivery	Russian Journal of Bioorganic Chemistry	2015，41, 562-567	Jianrong Wu; Xiaobei Zhan; Zhiyong Zheng; Hongtao Zhang
33.	Quantitative analysis of integrin alpha 6 in bladder cancer cell lines	Progress in Biochemistry and Biophysics	2015，42, 468-475	Wei Lu; Ganglong Yang; Peng Xue; Changmei Liu, and Feng Guan
34.	Chemoenzymatic preparatio of (S)-p-nitrostyrene oxide from p-nitrophenacyl bromide by recombinant Escherichia coli cells expressing a novel halohydrin dehalogenase.	Catalysis Communication	2015,69,72-75	Die Hu a,1, Hui-Hua Ye b,1, Min-ChenWuc,⁎, Feng Feng b, Li-Juan Zhu b, Xin Yin a, Jian-Fang Li d,⁎
35.	Contribution of Disulfide Bridges to the Thermostability of a Type A Feruloyl Esterase from Aspergillus usamii	Plos One	2015,5,13	Xin Yin1☯, Die Hu1☯, Jian-Fang Li2, Yao He1, Tian-Di Zhu1, Min-Chen Wu3*
36.	Expression of a novel epoxide hydrolase of Aspergillus usamii E001 in Escherichia coli and its performance in resolution of racemic of racemic styrene oxide	J Ind Microbiol Biotechnol	2015,42:671-680	Die Hu · Cun‑Duo Tang · Biao Yang · Jia‑Chi Liu ·Tao Yu · Chao Deng · Min‑Chen Wu
37.	Improvement in the thermostability of a type A feruloyl esterase,AuFaeA, from Aspergillus usamii by iterative saturation mutagenesis	Appl Microbiol Biotechnol	2015,99:10047-10056	lXin Yin1 & Jian-Fang Li2 & Chun-Juan Wang2 & Die Hu1 & Qin Wu1 & Ying Gu3 Min-Chen Wu3
38.	Carbohydrate-based vaccine adjuvants-discovery and development	EXPERT OPINION ON DRUG DISCOVERY	2015, 10: 1133-1144.	Hu, Jing; Qiu, Liying; Wang, Xiaoli; Zou, Xiaopeng; Lu, Mengji; Yin, Jian

序号	论文题目	刊物名称	年卷期页	作者全名
1.	A dynamic pathway analysis approach reveals a limiting futile cycle inN-acetyl glucosamine overproducing Bacillus subtilis	Nature Communications	2016, 7:11933	Liu, YF ; Link, H ; Liu, L ; Du, GC; Chen, J; Sauer, U
2.	A GPI processing phospholipase A2, PGAP6, modulates Nodal signaling in embryos by shedding CRIPTO	The Journal of Cell Biology	2016, 215(5): 705-718	Gun-Hee Lee*, Morihisa Fujita*, Katsuyoshi Takaoka, Yoshiko Murakami, Yoshitaka Fujihara, Noriyuki Kanzawa, Kei-ichi Murakami, Eriko Kajikawa,Yoko Takada, Kazunobu Saito, Masahito Ikawa, Hiroshi Hamada, Yusuke Maeda, and Taroh Kinoshita (*These authors equally contributed)
3.	Targeted photodynamic killing of breast cancer cells employing heptamannosylated β-cyclodextrin-mediated nanoparticle formation of an adamantane-functionalized BODIPY photosensitizer	ACS Applied Materials &Interfaces	2016, 8（49）：33405-33411	Q. Zhang*, Y. Cai, X.-J. Wang, J.-L. Xu, Z. Ye, S. Wang, P. H. Seeberger, J. Yin*,
4.	DATEL: A Scarless and Sequence-Independent DNA Assembly Method Using Thermostable Exonucleases and Ligase	ACS Synthetic Biology	2016，5(9):1028-1032	Jin, P; Ding, WW ; Du, GC ; Chen, J ; Kang, Z
5.	Tumour-targeted drug delivery with mannose-functionalized nanoparticles self-assembled from amphiphilic β-cyclodextrins	Chemistry-A European Journal	2016,22（43）:15216-15221.	Z. Ye†, Q. Zhang†, S. Wang, P. Bharate, S. Varela-Aramburu, M. Lu, P. H. Seeberger, J. Yin
6.	Polyethyleneimine-functionalized boron nitride nanospheres as an efficient carrier for enhancing the immunostimulatory effect of CpG oligodeoxynucleotides.	Nanomedicine: Nanotechnology, Biology and Medicine	2016,12(2):540.	Zhang HJ, Zhi CY, Gao X-D
7.	Pathway engineering of Propionibacterium jensenii for improved production of propionic acid	Scientific Reports	2016, 6:19963	Liu, L ; Guan, NZ ; Zhu, GX ; Li, JH ; Shin, HD ; Du, GC; Chen, J
8.	Quantitative study of yeast Alg1 beta-1, 4 mannosyltransferase activity, a key enzyme involved in protein N-glycosylation.	BBA-general subjects	2016,1861 (1) : 2934-2941	Li S-T., Wang N., Xu S., Yin J, Nakanishi H*., Dean N, Gao X-D*
9.	Biotechnological production of alpha-keto acids: current status and perspectives	Bioresource Technology	2016. 219: 716-724.	Yang Song, Jianghua Li, Hyun-dong Shinc, Long Liu, Guocheng Du , Jian Chen
10.	Activation of glycerol metabolism in Xanthomonas campestris by adaptive evolution to produce a high-transparency and low-viscosity xanthan gum from glycerol	Bioresource technology	2016, 211, 390-397	Zichao Wang, Jianrong Wu, Li Zhu, Xiaobei Zhan*
11.	3D Structure and Interaction of p24β and p24δ Golgi Dynamics Domains: Implication for p24 Complex Formation and Cargo Transport	Journal of Molecular Biology	2016, 428(20):4087-4099	Masamichi Nagae, Tetsuya Hirata, Kana Morita-Matsumoto, Romina Theiler, Morihisa Fujita, Taroh Kinoshita, and Yoshiki Yamaguchi
12.	Biosynthesis of GPI-anchored proteins: special emphasis on GPI lipid remodeling	Journal of Lipid Research	2016, 57(1): 6-24	Taroh Kinoshita and Morihisa Fujita
13.	Folate-conjugated boron nitride nanospheres for targeted delivery of anticancer drugs	International Journal of Nanomedicine	2016,11:4573-4582	Feng SN, Zhang HJ, Yan T, Huang DD, Zhi CY, Nakanishi H, Gao X-D.
14.	Metabolic engineering of acid resistance elements to improve acid resistance and propionic acid production of Propionibacterium jensenii	Biotechnology and Bioengineering	2016. 113（6）: 1294-1304	Ningzi Guan,Jianghua Li,Hyun-dong Shin,Guocheng Du,Jian Chen,Long Liu
15.	Global Identification and Differential Distribution Analysis of Glycans in Subcellular Fractions of Bladder Cells	International Journal of Biological Sciences	2016, 12(7): 799-811	Ganglong Yang, Luyu Huang, Jiaxu Zhang, Hanjie Yu, Zheng Li, Feng Guan
16.	Effect of oxidation degrees of graphene oxide on the structure and properties of poly (vinyl alcohol) composite films	Composites Science and Technology	2016, 04, 004	Di Liu, Qibo Bian, Yan Li, Yaru Wang, Aimin Xiang, Huafeng Tian
17.	Effects of Rho1, a small GTPase on the production of recombinant glycoproteins in Saccharomyces cerevisiae	Microbial Cell Factories	2016，15(1):179	Xu, S ; Zhang, GY ; Zhang, HJ ; Kitajima, T ; Nakanishi, H ; Gao, XD
18.	Using carbohydrate-based biomaterials as scaffolds to control human stem cell fate	Organic & Biomolecular Chemistry	2016, 14（37）：8648-8658	Hu, J ; Seeberger, PH ; Yin, J
19.	Nanodelivery systems for enhancing the immunostimulatory effect of CpG oligodeoxynucleotides.	Materials Science and Engineering: C	2017,70(2):935-946	Zhang HJ, Gao X-D.
20.	Graphene oxide-chitosan nanocomposites for intracellular delivery of immunostimulatory CpG oligodeoxynucleotides.	Materials Science and Engineering: C.	2017，73:144-51	Zhang, HJ., Yan, T., Xu, S., Feng, SN., Huang, DD., Fujita, M., Gao, X.-D.
21.	Effect of deoxynivalenol detoxification by ozone treatment in wheat grains.	Food Control	2016, 66, 137-144.	Li Wang, Yingpeng Luo, Xiaohu Luo, Ren Wang, Yongfu Li, Yanan Li, Huili Shao, Zhengxing Chen.
22.	Metabolic engineering for amino-, oligo-, and polysugar production in microbes	Applied Microbiology and Biotechnology	2016. 100（6）: 2523-2533	Hossain Gazi Sakir，Shin Hyun-dong，Jianghua Li, Miao Wang,Guocheng Du,jian Chen,long Liu
23.	Combination of phenylpyruvic acid (PPA) pathway engineering and molecular engineering of L-amino acid deaminase improves PPA production with an Escherichia coli whole-cell biocatalyst	Applied Microbiology and Biotechnology	2016. 100（5）: 2183-2191	Hou, Y ; Hossain, GS; Li, JH ; Shin, HD ; Du, GC; Liu, L
24.	Arginine deiminase: recent advances in discovery, crystal structure, and protein engineering for improved properties as an anti-tumor drug,	Applied Microbiology and Biotechnology,	2016, 100(11)：4747–4760.	Han Ruizhi, Xu Guochao, Dong Jinjun, Ni Ye
25.	The promises and challenges of fusion constructs in protein biochemistry and enzymology	Applied Microbiology and Biotechnology	2016,100（19）:8273–8281	Haiquan Yang, Long Liu, Fei Xu
26.	Transporter engineering and enzyme evolution for pyruvate production from D/L-alanine with a whole-cell biocatalyst expressing the L-amino acid deaminase from Proteus mirabilis	RSC Advances	2016. 6(86), 82676-82684	Gazi Sakir Hossain, Hyun-dong Shin, Jianghua Li, Guocheng Du, Jian Chen and Long Liu
27.	Effects of mixed carbon sources on galactose and mannose content of exopolysaccharides and related enzyme activities inGanoderma lucidum	RSC Advances	2016, 6, 39284-39291	Lin Peng; Jie Li; Ying Liu; Zhenghong Xu; Jian-Yong Wu; Zhongyang Ding; Zhenghua Gu; Liang Zhang, and Guiyang Shi
28.	Generation and characterization of β1, 2-gluco-oligosaccharide probes from Brucella abortus cyclic β-glucan and their recognition by C-type lectins of the immune system	Glycobiology	2016, 26(10):1086-1096	Hongtao Zhang*, Angelina S Palma, Yibing Zhang, Robert A Childs, Yan Liu, Daniel A Mitchell, Leticia S Guidolin, Wilfried Weigel, Barbara Mulloy, Andrés E Ciocchini, Ten Feizi, and Wengang Chai
29.	Copper-Catalyzed Regioselective Sulfenylation of Indoles with Arylsulfonyl Chlorides	Asian Journal Of Organic Chemistry	2016.5：625-628	Zhimeng Wu, Yan-Chun Li，Wen-Zhang Ding, Tao Zhu Shao-Zhong Liu， Xuehong Ren,and Liang-Hua Zou
30.	Two-step production of phenylpyruvic acid from L-phenylalanine by growing and resting cells of engineered Escherichia coli: Process optimization and kinetics modeling.	PLoS ONE	2016,11(11):e0166457	Hou, Y ; Hossain, GS ; Li, JH ; Shin, HD ; Liu, L ; Du, GC; Chen, J
31.	Effect of ozone treatment on deoxynivalenol and wheat quality	PLoS ONE	2016. 11(11): e0166457	Li Wang, Huili Shao, Xiaohu Luo, Ren Wang, Yongfu Li, Yanan Li, Yingpeng Luo, Zhengxing Chen
32.	Significantly enhancing recombinant alkaline amylase production in Bacillus subtilis by integration of a novel mutagenesis-screening strategy with systems-level fermentation optimization	Journal of Biological Engineering	2016, 10:13	Yingfang Ma, Wei Shen, Xianzhong Chen, Long Liu, Zhemin Zhou, Fei Xu and Haiquan Yang
33.	Differential effects of Pax3 on expression of polysialyltransferases STX and PST in TGF-β-treated normal murine mammary gland cells	Experimental Biology and Medicine	2017，242(2):177-183	Dong Guo, Jia Guo, Xiang Li, Feng Guan
34.	Quantitative analysis of differential proteome expression in epithelial-tomesenchymal transition of bladder epithelial cells using SILAC method	Molecules	2016, 21(1):84-93	Ganglong Yang , Wei Lu , Di Yu , Chenwen Sun , Jia Guo , Zheng Li and Feng Guan
35.	Modification of aspartokinase III and dihydrodipicolinate synthetase increases the production of l-lysine in Escherichia coli	Biochemical Engineering Journal	2016，114：79–86	Xu, JZ ; Han, M ; Ren, XD ; Zhang, WG
36.	Enhanced expression of polysialic acid correlates with malignant phenotype in breast cancer cell lines and clinical tissue samples	International Journal of molecular medicine	2016, 37(1):197-206	Xin Wang, Xiang Li, Yingnan Zeng, Fa He, Xiaomin Yang, Feng Guan
37.	Enhanced production of N-acetyl-d-neuraminic acid by whole-cell bio-catalysis of Escherichia coli	Journal of Molecular Catalysis B: Enzymatic	2016,125:42-48	Zhou, JB ; Chen, XZ; Lu, LP ; Govender, A ; Yang, HQ ; Shen, W
38.	Synthesis of Rare Pentoses Using Microbial and Enzymatic Reactions	Current Organic Chemistry	2016, 20, 1456-1464	Li Z j.,Gao X-D, Cai L
39.	Recent progress of on-resin cyclization for the synthesis of cyclopeptidemimics	Chinese Chemical Letters	2016，27(12):1731-1739	Zhi-Meng Wu, , Shao-Zhong Liu, Xiao-Zhong Cheng, Wen-Zhang Ding, Tao Zhu, Bing Chen
40.	Production and Rheological Properties of Welan Gum Produced by Sphingomonas sp. ATCC 31555 with Different nitrogen Sources	Journal of Molecular Microbilogy and Biotechnology	2016,DOI:10.1159/000452835	Xiaopeng Xu, Zuoming Nie, Zhiyong Zheng, Li Zhu, Xiaobei Zhan
41.	Production of encapsulated creatinase using yeast spores	Bioengineered	2016:09:00	Kong J., Li Z., Zhang H., Gao X-D* and Nakanishi H*
42.	Effect of hops beta acids on the survival of unstressed- or acid-stress-adaped-listeria monoctogenes and on the quality and sensory attributes of commercially cured ham slices	Journal of Food Science	2016, doi:10.1111/1750-3841	Li Wang, Amanda Gipe Mckeith, Cangliang Shen, Kelsey Carter, Alyssa Huff, Russell McKeith, Xinxia Zhang, Zhengxing Chen
43.	Consecutive hydrolysis of creatinine using creatininase and creatinase encapsulated in Saccharomyces cerevisiae spores,	Biotechnology Letters	2017，39 (2) : 261-267	Kong J., Li Z., Zhang H., Gao X-D* and Nakanishi H*
44.	Efficient whole-cell biocatalyst for Neu5Ac production by manipulating synthetic, degradation and transmembrane pathways	Biotechnology Letter	2016, 46(8):1-9	Deqiang Zhu, Xiaobei Zhan*, Jianrong Wu, Minjie Gao, Zhongsheng Zhao.
45.	Iron overload induced by ferric ammonium citrate triggers reactive oxygen species-mediated apoptosis via both extrinsic and intrinsic pathways in human hepatic cells	Human and Experimental Toxicology	2016, 35(6):598-607	Shiwei Li, Changmei Liu, Jia Guo, AM Marcondes, J Deeg, Xiang Li, Feng Guan
46.	Improved 1, 2, 4-butanetriol production from an engineeredEscherichia coliby co-expression of different chaperone proteins	World Journal of Microbiology and Biotechnology	2016, 32(9): 149	Lu, XY ; He, SY; Zong, H ; Song, J; Chen, W ; Bin, ZG
47.	overproduction, purification, and property analysis of an extracellular recombinant fructosyltransferase	European Food research technology	2016, 242(7): 1159-1168	Wenwen Guo, Haiquan Yang,Shumin Qiang,You Fan,Wei Shen,Xianzhong Chen
48.	Synthesis and biological evaluation of nitric oxide (NO)-hydrogen sulfide (H2S) releasing derivatives of (S)-3-n-butylphthalide as potential antiplatelet agents	Chinese Journal of Natural Medicines	2016,14(12):953-960	WANG Xiao-Li, WANG Zhao-Ya, LING Jing-Jing, ZHANG Yi-Hua, YIN Jian
49.	Current status and applications of aminoglycoside microarrays	Pakistan Journal of Pharmaceutical Sciences	2016,29(5):1869-1876	Xiaoli Wang, Xueyu Wang, Beilei Zhang, Dawei Song, Jing Hu, Jian Yin
50.	Role of Glycans in Cancer Cells Undergoing Epithelial–Mesenchymal Transition	Frontiers in Oncology	2016, 6:33	Xiang Li, Xin Wang, Zengqi Tan, Si Chen, Feng Guan
51.	Recent advances in synthetic carbohydrate-based humanimmunodeficiency virus vaccines	Virologica Sinica	2016, 31, 110-117	Zhenyuan Wang, Chunjun Qin, Jing Hu, Xiaoqiang Guo and Jian Yin*
52.	Improved temperature characteristics of anAspergillus oryzaeGHF11 Xylanase, by In Silico design and site-directed mutagenesis	Biotechonology and Bioprocess Enigeering	2016, 21, 704-711	Die Hu, Jianfang Li, Qin Wu, Jia Zang, Jianqing Cheng, Minchen Wu
53.	Kinetic resolution of racemic styrene oxide at a high concentration by recombinant Aspergillus usamii epoxide hydrolase in an n-hexanol/buffer biphasic system.	Jounal of Biotechnology	2016, 236, 152-158	Die Hu, Rui Wang, Xiao-Ling Shi, Hui-Hua Ye, Qin Wu, Minchen Wu

1.Yanfeng Liu, Jianghua Li, Guocheng Du, Jian Chen, Long Liu. Metabolic engineering ofBacillus subtilisfueled by systems biology: recent advances and future directions.

Biotechnology Advances.2017, 35: 20-30.IF=10.597

2.Yi-Shi Liu, Xin-Yu Guo, Tetsuya Hirata, Yao Rong, Daisuke Motooka, Toshihiko Kitajima, Yoshiko Murakami, Xiao-Dong Gao, Shota Nakamura, Taroh Kinoshita, and Morihisa Fujita. N-Glycan dependent protein folding and ER retention regulates GPI-anchor processing.

Journal of Cell Biology. 2017,DOI:10.1083/jcb.201706135.IF=7.955

3.Huijie Zhang, Dandi Huang, Chenxi Yuan, Ting Yan, Shini Feng, Hideki Nakanishi, Xiao-Dong Gao. Genetically engineered yeast spores as chitosan microspheres for intracellular delivery of immunostimulatory CpG oligodeoxynucleotides.

Journal of Controlled Release. 2017,259:e50.IF=7.786

4.Huijie Zhang, Wei Chen, Kai Gong, Jinghua Chen. Nanoscale Zeolitic Imidazolate Framework-8 as Efficient Vehicles for Enhanced Delivery of CpG Oligodeoxynucleotides.

ACS Applied Materials & Interfaces. 2017, 9:31519-31525.IF=7.504

5.Li Wang, Zhi-Yi Hu, Xiao-Yu Yang, Bo-Bo Zhang, Wei Geng, Gustaaf Van Tendelooce, Bao-Lian Su. Polydopamine nanocoated whole-cell asymmetric biocatalyst.

Chemical Communications. 2017, 53, 6617–6620.IF=6.319

6.Quan Zhang, Ying Cai, Qiu-Yan Li, Lin-Na Hao, Zheng Ma, Xiao-Jun Wang, Jian Yin. Targeted Delivery of a Mannose-Conjugated BODIPYPhotosensitizer by Nanomicelles for Photodynamic Breast CancerTherapy.

Chemistry-A European Journal. 2017, 23(57):14307-14315.IF=5.771

7.Meixi Ling, Yanfeng Liu, Jianghua Li, Hyun-dong Shin, Guocheng Du, Long Liu.Combinatorial promoter engineering of glucokinase and phosphoglucoisomerase for improved N-acetylglucosamine production inBacillus subtilis.

Bioresource Technology. 2017. 245: 1093-1102.IF=5.651

8.Yunfeng Zhang, Hao Huang, Xinhui Yao, Guocheng Du, Jian Chen, Zhen Kang.High-yield secretory production of stable, active trypsin through engineering of the N-terminal peptide and self-degradation sites inPichia pastoris.

Bioresource Technology. 2018, 247: 81-87.IF=5.651

9.JianrongWu, Xudong Fu, Yun Jiang, Xu Ma, Hongtao Zhang, Xiaobei Zhan. Dipotassium phosphate improves the molecular weight stability of polysialic acid inEscherichia coliK235 culture broth.

Bioresource Technology. 2018, 247:30-35.IF=5.65

10.Sheng-Tao Li, NingWang,Xin-Xin Xu, Morihisa Fujita, Hideki Nakanishi, ToshihikoKitajima, Neta Dean, Xiao-Dong Gao. Alternative routes for synthesis of N-linked glycans by the Alg2 mannosyltransferase.

Faseb journal,2017,10.1096/fj.201701267RIF: 5.5

11.Song Tang, Rukuan Liu, Fubao Fuelbiol Sun, Chunying Dong, Rui Wang, Zhongyuan Gao, Zhanying Zhang, Zhihong Xiao,Changzhu Li, Hui Li. Bioprocessing of tea oil fruit hull with acetic acid organosolv pretreatment in combination with alkaline H₂O₂.

Biotechnology for Biofuels. 2017, 10:86.IF=5.2

12.Xiaozhong Cheng, Tao Zhu, Haofei Hong, Zhifang Zhou and Zhimeng Wu. Sortase A-mediated on-resin peptide cleavage and in situ ligation: an efficient one-pot strategy for the synthesis of functional peptides and proteins.

Organic chemistry frontiers. 2017, 4: 2058.IF=4.955

13.Shuqin Xu, Xuanyue Zhang, Bo Duan, Jinghua Chen. An engineered platform based on chitin-affinity immobilization for producing low molecular weight heparin.

Carbohydrate Polymers. 2017, 177: 297-305.IF=4.811

14.Zichao Wang, Jianrong Wu, Li Zhu, Xiaobei Zhan. Characterization of xanthan gum produced from glycerol by a mutant strainXanthomonas campestrisCCTCC M2015714.

Carbohydrate Polymers. 2017, 157: 521-526.IF=4.8

15.Liang Y, Zhu L, Ding H, Gao MJ, Zheng ZY, Wu JR, Zhan XB. Enhanced production of curdlan by coupled fermentation system of Agrobacterium sp. ATCC 31749 and Trichoderma harzianum GIM 3.442.

Carbohydrate Polymers.2017, 157: 1687-1694.IF=4.8

16.Zhang Hao, Zhou Xing, Wang Tao, He Jian, Yue Ming, Luo Xiaohu, Wang Li, Wang Ren, Chen Zhengxing. Enzymatically modified waxy corn starch with amylosucrase: The effect of branch chain elongation on structural and physicochemical properties.

FOOD HYDROCOLLOIDS. 2017,63:518-524.IF=4.747

17.Hideki Nakanishi, Feng Li, Baoxian Han, Seisuke Arai, Xiao-Dong Gao. Yeast cells as an assay system for in vivo O-GlcNAc modification.

BBA-general subjects. 2017,1861(5 Pt A): 1159.IF=4.702

18.Shen-Tao Li, Ning Wang, Sha Xu, Jian Yin, Hideki Nakanishi, Neta Dean, Xiao-Dong Gao. Quantitative study of yeast Alg1 beta-1,4 mannosyltransferase activity,a key enzyme involved in protein N-glycosylation.

BBA-general subjects. 2017,1861(1 Pt A): 2934-2941.IF=4.702

19.Zhang Hao, Zhou Xing, He Jian, Wang Tao, Luo Xiaohu, Wang Li, Wang Ren, Chen Zhengxing. Impact of amylosucrase modification on the structural and physicochemical properties of native and acid-thinned waxy corn starch.

FOOD CHEMISTRY. 2017,220:413-419.IF=4.529

20.Emmanuel Matabaro, Zeng’an He, Yi-Shi Liu, Hui-Jie Zhang, Xiao-Dong Gao, Morihisa Fujita. Molecular switching system using glycosylphosphatidylinositol to select cells highly expressing recombinant proteins.

Scientific Reports. 2017, 7: 4033.IF=4.259

21.Xinrui Zhao, Haofei Hong, Xiaozhong Cheng, Shaozhong Liu, Tao Deng, Zhongwu Guo, Zhimeng Wu. One-step purification and immobilization of extracellularly expressed sortase A by magnetic particles to develop a robust andrecyclable biocatalyst.

Scientific Reports. 2017, 7: 6561.IF=4.259

22.Haitian Fu, Liping Teng, Ruizhen. Bai, Chao Deng, Guozhong Lv, Jinghua. Chen. Application of acellular intima from porcine thoracic aorta in full-thickness skin wound healing in a rat model.

Materials Science and Engineering C. 2017, 71:1135-1144.IF=4.164

23.Lipeng Qiu, Meiling Zhu, Kai Gong, Huanhuan Peng, Lu Ge, Li Zhao, Jinghua Chen. pH-triggered degradable polymeric micelles for targeted anti-tumor drug delivery.

Materials Science and Engineering C. 2017, 78: 912-922.IF=4.164

24.Leo D.Bemena, Omar Mukama, Aaron M Neiman, Zijie Li, Xiao-Dong Gao, Hideki Nakanishi. In vitro reconstitution of the yeast spore wall dityrosine layer to disclose the mechanism of its assembly.

Journal of Biological Chemsitry. 2017, DOI 10.1074/JBCM117.786202.IF=4.125

25.Guo Chaolin, Zhao Liting, Wang Feng, Lu Jian, Ding Zhongyang, Shi Guiyang. Beta-Carotene from Yeasts Enhances LaccaseProduction ofPleurotuseryngii var. ferulaein Co-culture.

FRONTIERS IN MICROBIOLOGY. 2017.8.1101.IF=4.076

26.Zhilei Zhou,Shuangping Liu,Xiangwei Kong, Zhongwei Ji, Xiao Han, Jianfeng Wu, Jian Mao. Elucidation of the aroma compositions of Zhenjiang aromatic vinegar using comprehensive two dimensional gas chromatography coupled to time-of-flight mass spectrometry and gas chromatography-olfactometry.

Journal of Chromatography A. 2017, 1487, 218-226.IF=3.981

27.HaitianFu, Chao Deng, Liping Teng, Zhi Cai, Jinghua Chen, Guozhong Lu. Effect of heparan sulfate mimetics fromEscherichia coliK5 polysaccharide on SDF-1/CXCL12-induced endothelial progenitor cells in vitro.

International journal of biological macromolecules. DOI 10.1016/j.ijbiomac.2017.10.132.IF=3.671

28.Shuqin Xu, Meiling Qiu, Xuanyue. Zhang, Jinghua Chen. Expression and characterization of an enhanced recombinant heparinase I with chitin binding domain, International journal of biological macromolecules.

International journal of biological macromolecules. 2017, 105: 1250-1258.IF=3.671

29.Wu JR, Fu H, Zhan XB, Zheng ZY, Zhang, HT. Preparation and characterization of a novel polysialic acid–hyaluronan graft copolymer potential as dermal filler.

International Journal of Biological Macromolecules. 2017, 99:692-698.IF=3.67

30.Yang Gu, Jieying Deng, Yanfeng Liu, Jianghua Li, Hyun-dong Shin, Guocheng Du, Long Liu.Rewiring the glucose transportation pathway and central metabolic pathway for overproduction of N-acetylglucosamine inBacillus subtilis.

Biotechnology Journal. 2017, DOI: 10.1002/biot.201700020.IF=3.649

31.Chang Su, Jinsong Gong, Rongxian Zhang, Liyan Tao, Wenfang Dou, Dandan Zhang,Heng Li, Zhenming Lu, Zhenghong Xu, Jinsong Shi. A novel alkaline surfactant-stable keratinase with superior feather-degrading potential based on library screening strategy.

International journal ofbiologicalmacromolecules. 2017, 95: 404-411.IF=3.617

32.Liang Y, Zhu L, Ding H, Gao MJ, Zheng ZY, Wu JR, Zhan XB. Influence of Tween-80 on the production and structure of water-insoluble curdlan from Agrobacterium sp.

International Journal of Biological Macromolecules. Accepted.IF=3.6

33.Ting Yan, Huijie Zhang, Dandi Huang, Shini Feng, Morihisa Fujita, Xiao-Dong Gao. Chitosan-Functionalized Graphene Oxide as a Potential Immunoadjuvant.

Nanomaterials. 2017, 7:59.IF=3.55

34.Chuang Li, Die Hu, Xuncheng Zong, Lei Feng, Minchen Wu. Asymmetric hydrolysis of styrene oxide by PvEH2, a novel Phaseolus vulgaris epoxide hydrolase with extremely high enantioselectivity and regioselectivity.

Catalysis Communications. 2017, 102(12): 57-61.IF=3.33

35.Chunjun Zhan, Yankun Yang, Zhenyang Zhang, Xiang Li, Xiuxia Liu, Zhonghu Bai. Transcription factor Mxr1 promotes the expression of Aox1 by repressing glycerol transporter 1 inPichia pastoris.

FEMS yeast research. 2017,4,fox015.IF=3.299

36.Xiang Li, Yankun Yang, Chunjun Zhan, Zhenyang Zhang, Xiuxia Liu, Hebin Liu, Zhonghu Bai. Transcriptional analysis of impacts of glycerol transporter 1 on methanol and glycerol metabolism inPichia pastoris.

FEMS Yeast Research. 2017,fox081.IF=3.299

37.Die Hu, Cunduo Tang, Chuang Li, Tingting Kan, Xiaoling Shi, Lei Feng, Minchen Wu. Stereoselective hydrolysis of epoxides by reVrEH3, a novel vigna radiata epoxide hydrolase with high enantioselectivity or high and complementary regioselectivity.

Journal of Agricultural and Food Chemistry. 2017, 65(45): 9861-9870.IF=3.15

38.Fubao Fuelbiol Sun, Huimin Yang, Renhui Bai, Xu Fang, Fei Wang, Jing He, MaobingTu. Enhanced heterologous expression of Trichodermareesei Cel5A / Cel6A inPichia pastoriswith extracellular co-expression of Vitreoscillahemoglobin.

Journal of Chemical Technology & Biotechnology. 2017, DOI:10.1002/jctb.5433.IF=3.1

39.Wang L, Ding Y, Zhang X, Chen, Zheng xing. Effect of electron beam on the functional properties and structure of defatted wheat germ proteins.

Journal of Food Engineering. 2017, 202:9-17.IF=3.099

40.Wang Tao, Wang Ren, Chen Zhengxing, Zhong Qixin. Magnetization of eugenol to fabricate magnetic-responsive emulsions for targeted delivery of caffeic acid phenethyl ester.

RSC ADVANCES. 2017,7:43455-43463.IF=3.108

41.Luo Xiaohu, Qi Lijun, Liu Yuntao, Wang Ren, Yang Dan, Li Ke, Wang Li, Li Yanan, Zhang Yuwei, Chen Zhengxing. Effects of Electron Beam Irradiation on Zearalenone and Ochratoxin A in Naturally Contaminated Corn and Corn Quality Parameters.

TOXINS. Accepted.IF=3.030

42.Qiong Wang, Feng Wang, Zhenghong Xu, Zhongyang Ding. Bioactive Mushroom Polysaccharides: A Reviewon Monosaccharide Composition, Biosynthesisand Regulation.

Molecules. 2017, 22(6), 955.IF=2.861

43.Ping-Gui Li, Yan-Chun Li, Tao Zhu, Liang-Hua Zou, Zhimeng Wu. Hydroxysulfonylation of Quinones withAryl(alkyl)sulfonylHydrazides for the Synthesis of 1,4-Dihydroxy-2- aryl(alkyl)sulfonylbenzenes.

Europe Journal of organic chemistry. 2017, 6081-6084.IF=2.834

44.Xiuxia Liu, Sun Yang, Fen Wang, Xiaofeng Dai, Yankun Yang, Zhonghu Bai. Comparative analysis of theCorynebacterium glutamicumtranscriptome in response to changes in dissolved oxygen levels.

Journal of Industrial Microbiology & Biotechnology. 2017. 44(2): p. 181-195.IF=2.81

45.Wenwen Ding, Huanjiao Weng, Guocheng Du, Jian Chen, Zhen Kang. 5-Aminolevulinic acid production from inexpensive glucose by engineering the C4 pathway inEscherichia coli.

J Ind Microbiol Biotechnol. 2017, 44:1127-1135.IF=2.81

46.Yang Sun, Wenwen Guo, Fen Wang, Chunjun Zhan, Yankun Yang, Xiuxia Liu, Zhonghu Bai. Transcriptome analysis ofCorynebacterium glutamicumin the process of recombinant protein expression in bioreactors.

PLOS ONE. 2017. 12(4): p. e0174824.IF=2.806

47.Zhenyu Zhang, Xiaojiao Wang, Tangjie Gao, ChunyinGu, Fubao Sun, Lin Yu, Jinguang Hu. Characterization of the complex involved in regulating V-ATPase activity of the vacuolar and endosomal membranes.

Journal of Bioenergetics and Biomembranes. 2017, 49:347-355.IF=2.6

48.Wang Li, Zhang Xinxia, Liu Fengru, Ding Yuanyuan, Wang Ren, Luo Xiaohu, Li Yanan, Chen Zhengxing. Study of the functional properties and anti-oxidant activity of pea protein irradiated by electron beam.

Innovative Food Science & Emerging Technologies. 2017,41:124-129.IF=2.573

49.Zhimeng Wu, Xiaozhong Cheng, Haofei Hong, Xinrui Zhao, Zhifang Zhou. New potent and selective avb3 integrin ligands: Macrocyclic peptides containing RGD motif synthesized by sortase A-mediated ligation.

Bioorganic & Medicinal Chemistry Letters. 2017, 27, 1911-1913.IF =2.454

50.Jing Hu,Chris Weise,Christoph Böttcher,Hua Fan, Jian Yin. Expression, purification and structural analysis of functional GABA transporter 1 using the baculovirus expression system.

Beilstein Journal of Organic Chemistry. 2017, 13, 874-882.IF=2.337

51.Toshihiko Kitajima, Yuanling Jia, Akiko Komatsuzaki, Juan Cui, Fumiko Matsuzawa, Sei-Ichi Aikawa, Xiao-Dong Gao and Yasunori Chiba. Structural modeling and mutagenesis of endo-β-N-acetylglucosaminidase fromOgataea minutaidentifies the importance of Trp295 for hydrolytic activity.

Journal of Bioscience and Bioengineering. 2017, In press.IF=2.24

52.Xiaolu Wei,Shuangping Liu,Jianshen Yu,Yongjian Yu,Shenghu Zhu,Zhilei Zhou, Jian Hu, Jian Mao. Innovation Chinese Rice Wine Brewing Technology By Bi-acidification To Exclude Rice Soaking Process.

Journal of Bioscience and Bioengineering. 2017, 123, 4, 460-465.IF=2.24

53.Masamichi Nagae, Dorothee Liebschner, Yusuke Yamada, Kana Morita-Matsumoto, Naohiro Matsugaki, Toshiya Senda, Morihisa Fujita, Taroh Kinoshita, Yoshiki Yamaguchi. Crystallographic analysis of murine p24γ2 Golgi dynamics domain.

Proteins. 2017, 85: 764.IF=2.289

54.Jun Lv, Bo-Bo Zhang, Xiao-Dong Liu, Chan Zhang, Lei Chen, Gan-Rong Xu, Peter C.K. Cheung. Enhanced production of natural yellow pigments from Monascuspurpureus by liquid culture: The relationship between fermentation conditions and mycelial morphology.

Journal of Bioscience and Bioengineering. 2017, 124, 452-458.IF=2.240

55.Jianfang Li, Chunjuan Wang, Die Hu, Fengjiao Yuan, Xueqing Li, Shihan Tang, Minchen Wu.Engineering a family 27 carbohydrate-binding module into anAspergillus usamiiβ-mannanase to perfect its enzymatic properties.

Journal of Bioscience and Bioengineering.2017, 123(3): 294-299.IF=2.240

56.Toshihiko Kitajima, YuanlingJia, Akiko Komatsuzaki, Juan Cui, Fumiko Matsuzawa, Sei-IchiAikawa, Xiao-Dong Gao, Yasunori Chiba. Structural modeling and mutagenesis of endo-b-N-acetylglucosaminidase fromOgataeaminuta identifies the importance of Trp295 for hydrolytic activity.

Journal of Bioscience and Bioengineering. Accepted.IF=2.240

57.Wu Xueyou, Ju Xingrong, Du Lihui, Yuan Jian, Wang Lifeng, He Rong, Chen Zhengxing. Production of Bacterial Ghosts from Gram-Positive Pathogen Listeria monocytogenes.

FOODBORNE PATHOGENS AND DISEASE. 2017,14:1-7.IF=2.120

58.Qimin Shi, Anjian Wang, Zhonghua Lu, Chunjun Qin, Jing Hu, Jian Yin. Overview on the antiviral activities and mechanisms of marinepolysaccharides from seaweeds.

Carbohydrate Research. 2017, 453-454, 1-9.IF=2.096

59.Aimin Li, Li Cai, Zhou Chen, Mayan Wang, Ning Wang, Hideki Nakanishi, Xiao-Dong Gao, Zijie Li. Recent advances in the synthesis of rare sugars usingDHAP-dependent aldolases.

Carbohydrate Research. 2017, 452, 108-115.IF=2.096

60.Leo D.Bemena, Omar Mukama, Ning Wang, Xiao-Dong Gao, Hideki Nakanishi. Characterization of a yeast sporulation-specific P450 family protein, Dit2, using an in vitro assay to crosslink formyl tyrosine.

The Journal of Biochemistry. 2017, DOI:10.1093/jb/mvx067.IF=2.082

61.Hua-Ping Pan, Ning Wang, Hiroyuki Tachikawa, Xiao-Dong Gao, Hideki Nakanishi. Osw2 is required for proper assembly of glucan and/or mannan layers of the yeast spore wall.

The Journal of Biochemistry. Accepted.IF=2.082

62.Wang L, Wang Y, Shao H, Chen, Zheng xing. In vivo toxicity assessment of deoxynivalenol-contaminated wheat after ozone degradation.

Food Additives & Contaminants Part A Chemistry Analysis Control Exposure & Risk Assessment. 2017, 34(1):103.IF=2.047

63.Hua-Ping Pan, Ning Wang, Hiroyuki Tachikawa, Hideki Nakanishi, Xiao-Dong Gao. β-1,6-glucan synthesis-associated genes are required forproper spore wall formation inSaccharomyces cerevisiae.

Yeast. 2017, 34: 431-446.IF=1.99

64.Xin-Xin Xu, Akiko Komatsuzaki, Yasunori Chiba, Xiao-Dong Gao, Takehiko Yoko-o. PER1, GUP1, and CWH43 of methylotrophic yeast Ogataeaminuta are involved in cell wall integrity.

Yeast. 2017, DOI.10.1002/yea.3285.IF=1.99

65.Wuqiong Song, Juntao Cai, Xiaopeng Zou, Xiaoli Wang, Jing Hu, Jian Yin. Applications of controlled inversion strategies in carbohydrate synthesis.

Chinese Chemical Letters. 2017, Online.IF=1.932

66.Zhi-Meng Wu, Shao-Zhong Liu, Xiao-Zhong Cheng, Xin-Rui Zhao, Hao-Fei Hong. High yield synthesis of cyclic analogues of antibacterial peptides P-113 by Sortase A-mediated ligation and their conformation studies.

Chinese Chemical Letters. 2017, 28, 553–557.IF=1.932

67.Zhifang Zhou, Han Lin, Chen Li, Zhimeng Wu. Recent progress of fully synthetic carbohydrate-based vaccine using TLR agonist as build-in adjuvant.

Chinese Chemical Letters. Doi.org/10.1016/j.cclet.2017.09.047.IF=1.932

68.Ning-Wang, Sheng-Tao Li, Tian-Tian Lu, Hideki Nakanishi, Xiao-Dong Gao. Approaches towards the core pentasaccharide in N-linked glycans.

Chinese Chemical Letters. 2017, doi 10.1016/j.cclet.2017.09.044.IF=1.932

69.Juan Zhang, Yanqiu Cai, Guocheng Du, Jian Chen, Miao Wang, and Zhen Kang. Evaluation and application of constitutive promoters for cutinase production bySaccharomyces cerevisiae.

Journal of Microbiology. 2017, 55: 538–544.IF=1.924

70.Chunshuai Wang, Jing Liu, Xuyan Han, Chang Liu, Yaping Tian, Nandi Zhou. UV-visible spectroscopic detection of kanamycin based on target-induced growth of gold nanoparticles.

Analytical Methods. 2017, 9(33): 4843-4850.IF=1.900

71.Wu JR, Zhang JB, Wang PP, Zhu L, Gao MJ, Zheng ZY, Zhan XB. Production of rhamnolipids by semi-solid-state fermentation withPseudomonas aeruginosaRG18 for heavy metal desorption.

Bioprocess Biosyst Eng. 2017, 40:1611–1619.IF=1.87

72.Xueqing Li, Qin Wu, Die Hu, Rui Wang, Yan Liu, Minchen Wu.Improving the temperature characteristics and catalytic efficiency of a mesophilic xylanase fromAspergillus oryzae, AoXyn11A, by iterative mutagenesis based on in silico design.

AMB Express.2017, 7: 97.IF=1.83

73.Jianrong Wu, Jingbo Zhang, Panpan Wang, Li Zhu, Minjie Gao, Zhiyong Zheng, Xiaobei Zhan. Production of rhamnolipids by semi-solid-state fermentation withPseudomonas aeruginosaRG18 for heavy metal desorption.

Bioprocess and Biosystems Engineering. 2017, 40: 1611-1619.IF=1.8

74.Rui Wang, Die Hu, Xuncheng Zong, Jinping Li, Minchen Wu.Enantioconvergent hydrolysis of racemic styrene oxideat high concentration by a pair of novel epoxide hydrolasesinto (R)-phenyl-1,2-ethanediol.

Biotechnology Letters.2017, 39(12): 1917-1923.IF=1.73

75.Zhu DQ, Zhan XB, Wu JR, Gao MJ, Zhao Z. Efficient whole-cell biocatalyst for Neu5Ac production by manipulating synthetic, degradation and transmembrane pathways.

Biotechnology Letters. 2017, 391: 55-63.IF=1.73

76.Wenwen Ding, Huanjiao Weng, Peng Jin, Guocheng Du, Jian Chen, Zhen Kang. Scarless assembly of unphosphorylated DNA fragments with a simplified DATEL method.

Bioengineered. 2017, 8:296-301.IF=1.691

77.Aisikaer Ai-Lati,Shuangping Liu,Zhongwei Ji,Hao Zhang, JianMao. Structure and bioactivities of a polysaccharide isolated from Ganodermalucidum in submerged fermentation.

Bioengineered. 2017, 8, 5, 565-571.IF=1.691

78.Zhen Kang, Wenwen Ding, Xu Gong, Qingtao Liu, Guocheng Du, Jian Chen. Recent advances in production of 5-aminolevulinic acid using biological strategies.

World J Microbiol Biotechnol. 2017, 33:200.IF=1.65

79.Xu XP, NieZM, Zheng ZY, Zhu L, Zhang HT, Zhan XB. Different nitrogen sources change the transcriptome of welan gum-producing strain Sphingomonas sp. ATCC 31555.

Archivies of Microbiology. 2017, 199: 1055-1064.IF=1.5

80.Xu XP, Nie ZM, Zheng ZY, Zhu L, Zhan XB.Production and Rheological Properties of Welan Gum Produced by Sphingomnas sp ATCC 31555 with Different Nitrogen Sources.

journal of molecular microbiology and biotechnology Journal of Molecular Microbiol and Biotechnol. 2017, 27:55-63.IF=1.5

81.Jinsong Gong, Xumei Liu, Mingjie Zhang, Heng Li, Yan Geng, Hui Li, Jing Li, Zhenming Lu, Zhenghong Xu, Jinsong Shi. Purification and characterization of a high salt-tolerant alginate lyase from Cobetia sp. WG-007.

Biotechnology and applied biochemistry. 2017, 64(4): 519-524.IF=1.413

82.Wang ZC, Wu JR, Zhu L, Zhan XB. High Production of Xanthan Gum by a GlycerolTolerant StrainXanthomonas CampestrisWXLB-006.

Preparative Biochemistry and Biotechnology. 2017, 475: 468-472.IF=1.4

83.Xinrui Zhao, Haofei Hong, Zhimeng Wu. Efficient extracellular expression of transpeptidase sortase A inPichia pastoris.

Protein Expression and Purification. 2017, 133, 132-138.IF=1.351

84.Zhifang Zhou, Wenzhang Ding, Chen Li, Zhimeng Wu. Synthesis and immunological study of a wall teichoic acid-based vaccine againstE. faeciumU0317.

Journal of Carbohydrate Chemistry. DOI: 10.1080/07328303.2017.1390576.IF=0.671

85.Zhimeng Wu, Haofei Hong, Xinrui Zhao and Xun Wang. Efficient expression of sortase A fromStaphylococcus aureusinEscherichia coliand its enzymatic characterizations.

Bioresources and Bioprocessing. 2017，4:13.

1.Chunjun Qin, Benjamin Schumann, Xiaopeng Zou, Claney L. Pereira, Guangzong Tian, Jing Hu, Peter H. Seeberger, and Jian Yin. Total Synthesis of a Densely Functionalized Plesiomonas shigelloides Serotype 51 Aminoglycoside Trisaccharide Antigen.

Journal of the American Chemical Society.2018, 140: 3120-3127.

2.Zhou Ye, Wenrui Wu, Yufei Qin, Jing Hu, Chao Liu, Peter H. Seeberger, and Jian Yin. An Integrated Therapeutic Delivery System for Enhanced Treatment of Hepatocellular Carcinoma.

Advanced Functional Materials.2018, 28, 1706600.

3.Tetsuya Hirata, Sushil K. Mishra, Shota Nakamura, Kazunobu Saito, Daisuke Motooka, Yoko Takada, Noriyuki Kanzawa, Yoshiko Murakami, Yusuke Maeda, Morihisa Fujita, Yoshiki Yamaguchi, and Taroh Kinoshita. Identification of a Golgi GPI-N-acetylgalactosamine transferase with tandem transmembrane regions in the catalytic domain.

Nature Communications.2018, 9 (1): 405.

4.Jingjing Nie, Luyi Yuan, Ke Jin, Xuyan Han, Yaping Tian, and Nandi Zhou. Electrochemical detection of tobramycin based on enzymes-assisted dual signal amplification by using a novel truncated aptamer with high affinity.

Biosensors and Bioelectronics.2018, doi.org/10.1016/j.bios.2018.09.072.

5.Yaokang Wu, Taichi Chen, Yanfeng Liu, Xueqin Lv, Jianghua Li, Guocheng Du, Rodrigo Ledesma-Amaro, and Long Liu. CRISPRi allows optimal temporal control of N-acetylglucosamine bioproduction by a dynamic coordination of glucose and xylose metabolism inBacillus subtilis.

Metabolic Engineering.2018, 49:232-241.

6.Huijie Zhang, Ting Cheng, Li Lai, Shuhao Deng, Ruixi Yu, Lipeng Qiu, Juan Zhou, Guozhong Lu, Chunyi Zhi, and Jinghua Chen. BN nanospheres functionalized with mesoporous silica for enhancing CpG oligodeoxynucleotide-mediated cancer immunotherapy.

Nanoscale.2018, 10(30): 14516-14524.

7.Zhiyong Zheng, Yuqi Chen, Xiaobei Zhan, Minjie Gao, Zifan Wang. Mass transfer intensification in a novel airlift reactor assembly with helical sieve plates.

Chemical Engineering Journal. 2018,342:61-70.

8.Marie Rose Mukasekuru, Jinguang Hu, Xiaoqin Zhao, Fubao Sun, Kaneza Pascal, Hongyan Ren, and Junhua Zhang. High-solids enzymatic hydrolysis of alkaline-catalysed atmospheric glycerol organosolv-pretreated sugarcane bagasse at an extremely low enzyme loading.

ACS Sustainable Chemical Engineering. DOI:10.1021/acssuschemeng.8b01972 .

9.Jianrong Wu, Xudong Fu, Yun Jiang, Xu Ma, Hongtao Zhang, and Xiaobei Zhan. Dipotassium phosphate improves the molecular weight stability of polysialic acid inEscherichia coliK235 culture broth.

Bioresource Technology.2018, 247:30-35.

10.Wenlong Ma, Yanfeng Liu, Hyundong Shin, Jianghua Li, Jian Chen, Guocheng Du, and Long Liu. Metabolic engineering of carbon overflow metabolism ofBacillus subtilisfor improved N-acetyl-glucosamine production.

Bioresource Technology.2018, 250:642–649.

11.Xuyan Han, Yuhong Zhang, Jingjing Nie, Songyin Zhao, Yaping Tian, and Nandi Zhou. Gold nanoparticle based photometric determination of tobramycin by using new specific DNA aptamers

Microchimica Acta.2018, 185: 4.

12.Yishi Liu, Xinyu Guo,Tetsuya Hirata, Yao Rong, Daisuke Motooka, Toshihiko Kitajima,Yoshiko Murakami, Xiaodong Gao, Shota Nakamura, Taroh Kinoshita, and Morihisa Fujita. N-Glycan-dependent protein folding and endoplasmic reticulum retention regulate GPI-anchor processing.

Journal of Cell Biology. 2018, 217(2):585-599.

13.Tengfei Niu, Yanfeng Liu, Jianghua Li, Mattheos A.G. Koffas, Guocheng Du, Hal S. Alper, and Long Liu. Engineering a glucosamine-6-phosphate responsive glmS ribozyme switch enables dynamic control of metabolic flux inBacillus subtilisfor overproduction of N-acetylglucosamine.

ACS Synthetic Biology.DOI: 10.1021/acssynbio.8b00196.

14.Xiaopeng Zou, Chunjun Qin, Claney L. Pereira, Guangzong Tian, Jing Hu, Peter H. Seeberger, and Jian Yin. Synergistic Glycosylation as Key to the Chemical Synthesis of an Outer Core Octasaccharide of Helicobacter pylori

Chemistry-A European Journal.2018, 24: 2868-2872.

15.Juan Zhou, Huiyan Ying, Mingyu Wang, Dandan Su, Guozhong Lu, and Jinghua Chen. Dual layer collagen-GAG conduit that mimic vascular scaffold and promote blood vessel cells adhesion, proliferation and elongation.

Materials science & engineering C. 2018, 92: 447-452.

16.Toshihiko Kitajima, Wei Xue, Yi-Shi Liu, ChunDi Wang, SiSi Liu, Liu, Morihisa Fujita, Xiaodong Gao. Construction of green fluorescence protein mutant to monitor STT3B-dependent N-glycosylation.

FASEB Journal.2018, 285; 915-928.

17.Shini Feng, Huijie Zhang, Chunyi Zhi, Xiaodong Gao, and Hideki Nakanish. pH-responsive charge-reversal polymer-functionalized boron nitride nanospheres for intracellular doxorubicin delivery.

International Journal of Nanomedicine.2018, 13: 641-652.

18.Zecheng Jin, Toshihiko Kitajima, Weijie Dong, Yifan Huang, Weiwei Ren, Feng Guan, Yasunori Chiba, Xiaodong Gao, and Morihisa Fujita. Genetic disruption of multiple α1,2-mannosidases generates mammalian cells producing recombinant proteins with high-mannose-type N-glycans..

Journal of Biological Chemistry.2018, 293(15): 5572-5584.

19.Guangzong Tian, Jing Hu, Hengxi Zhang, Christoph Rademacher, Xiaopeng Zou, Hongning Zheng, Fei Xu, Xiaoli Wang, Torsten Linker, and Jian Yin. Synthesis and conformational analysis of linear homo- and heterooligomers from novel 2-C-branched sugar amino acids (SAAs)

Scientific Reports.2018, 8, 6625.

20.Xiaolong Zhang, Yanfeng Liu, Long Liu, Miao Wang, Jianghua Li, Guocheng Du, and Jian Chen. Modular pathway engineering of key carbon‐precursor supply‐pathways for improved N‐acetylneuraminic acid production in Bacillus subtilis.

Biotechnology and Bioengineering.2018, 115:2217–2231.

21.Zhengxiong Zhou, Qing Li, Hao Huang, Hao Wang, Yang Wang, Guocheng Du, Jian Chen, Zhen Kang. A microbial–enzymatic strategy for producing chondroitin sulfate glycosaminoglycans.

Biotechnology and Bioengineering.2018, 115:1561–1570.

22.Ying Liang, Li Zhu, MinjieGao, Zhiyong Zheng, Jianrong Wu, Xiaobei Zhan. Influence of Tween-80 on the production and structure of water-insoluble curdlan from Agrobacterium sp.

International Journal of Biological Macromolecules.2018, 106: 611-619.

23.Haitian Fua, Chao Deng, Liping Teng, Zhi Cai, Jinghua Chen, and Guozhong Lu. Effect of heparan sulfate mimetics from Escherichia coli K5 polysaccharide on SDF-1/CXCL12-induced endothelial progenitor cells in vitro.

International Journal of Biological Macromolecules.2018, 107: 2492-2500.

24.Jing Wu, Jiayi Yuan, Baotong Ye, Yaling Wu, Zheng Xu, Jinghua Chen, and Jingxiao Chen. Dual-Responsive Core Crosslinking Glycopolymer-Drug Conjugates Nanoparticles for Precise Hepatocarcinoma Therapy.

Frontiers in Pharmacology.2018, 9: 663.

25.Xinxin Xu, Shengtao Li, Ning Wang, Toshihiko Kitajima, Takehiko Yoko-o, Morihisa Fujita, Hideki Nakanishi, and Xiaodong Gao. Structural and functional analysis of Alg1 beta-1,4 mannosyltransferase reveals the physiological importance of its membrane topology.

Glycobiology. 2018 28(10):741-753

26.Haiquan Yang, Xiao Lu, Jinyuan Hu, Yuan Chen, Wei Shen, and Long Liu. Boosting extracellular protein secretion ofEscherichia colivia perturbing cell wall.

Applied and Environmental Microbiology.2018, DOI:10.1128/AEM.01382-18.

27.Wenlong Ma, Yanfeng Liu, Yue Wang, Xueqin Lv, Jianghua Li, Guocheng Du, and Long Liu. Combinatorial Fine-Tuning of GNA1 and GlmS Expression by 5’-terminus Fusion Engineering Leads to Overproduction of N-acetylglucosamine inBacillus subtilis.

Biotechnology Journal.DOI: 10.1002/biot.201800264.

28.Jialin Zheng, Heng Li, Xiaojuan Zhang, Min Jiang, Chunqin Luo, Zhenming Lu, Zhenghong Xu, and Jinsong Shi. Prebiotic Mannan-Oligosaccharides Augment the Hypoglycemic Effects of Metformin in Correlation with Modulating Gut Microbiota.

Journal of Agricultural and Food Chemistry.2018, 66, 5821−5831.

29.Jianrong Wu, Xiaobei Zhan, Liming Liu, and Xiaole Xia. Bioproduction, purification and application of polysialic acic.

Applied Microbiology and Biotechnology.2018, 102(22):9403-9409.

30.Min Yang, Haofei Hong, Shaozhong Liu, Xinrui Zhao, and Zhimeng Wu. Immobilization of Staphylococcus aureus Sortase A on Chitosan Particles and Its Applications in Peptide-to-Peptide Ligation and Peptide Cyclization.

Molecules.2018, 23, 192.

31.Lianghua Zou, Yanchun Li, Guipin Li, Zhimeng Wu. Solvent-Controlled α-Monobromination, α,α-Dibromination or Imidationof 1,3-Diketones with N-Bromosuccinimide.

European Journal of Organic Chemistry.10.1002/ejoc.201800994.

32.Wuqiong Song, Juntao Cai, Xiaopeng Zou, Xiaoli Wang, Jing Hu, and Jian Yin. Applications of controlled inversion strategies in carbohydrate synthesis

Chinese Chemical Letters.2018, 29, 27-34.

33.Fubao Sun, Huimin Yang, Renhui Bai, Xu Fang, Fei Wang, Jing He, and Maobing Tu. Enhanced heterologous expression of Trichoderma reesei Cel5A / Cel6A inPichia pastoriswith extracellular co-expression of Vitreoscilla hemoglobin.

Journal of Chemical Technology & Biotechnology.2018, 93 (1): 35-42.

34.Fubao Sun, Marie Rose Mukasekuru, Ling Tan, Junli Ren, Zhenxing Huang, Hongyan Ren, and Zhanying Zhang. Optimization of on-site cellulase preparation for efficient hydrolysis of atmospheric glycerol organosolv pretreated wheat straw.

Journal of Chemical Technology & Biotechnology.2018,93:2083–2092.

35.Chen Deng, Jianghua Li, Hyun-dong Shin, Guocheng Du, Jian Chen, and Long Liu. Efficient expression of cyclodextrin glycosyltransferase fromGeobacillus stearothermophilusin Escherichia coli by promoter engineering and downstream box evolution.

Journal of Biotechnology.2018, 266:77–83.

36.Leo Bemena, Omar Mukama, Ning Wang, Xiaodong Gao, and Hideki Nakanishi. Characterization of a yeast sporulation-specific P450 family protein, Dit2, using an in vitro assay to crosslink formyl tyrosine.

Journal of Biochemistry. 2018, 163: 123-131.

37.Zecheng Jin, Toshihiko Kitajima, Weijie Dong, Yi-Fan Huang, Wei-Wei Ren, Feng Guan, Yasunori Chiba, Xiao-Dong Gao and Morihisa Fujita. Genetic disruption of multiple α1,2-mannosidases generates mammalian cells producing recombinant proteins with high-mannose-type N-glycans.

Journal of Biochemistry.2018, 293(15):5572-5584.

38.Huaping Pan, Ning Wang, Hiroyuki Tachikawa, Xiaodong Gao, and Hideki Nakanishi. Osw2 is required for proper assembly of glucan and/or mannan layers of the yeast spore wall.

Journal of Biochemistry.2018, 163(4):293-304.

39.Xinxin Xu, Akiko Komatsuzaki, Yasunori Chiba, Xiaodong Gao, Takehiko Yoko-o. PER1, GUP1 and CWH43 of methylotrophic yeast Ogataea minuta are involved in cell wall integrity.

YEAST.2018; 35; 225-236.

40.Yanjun Chen, Wenfang Dou, Heng Li, Jinsong Shi, Zhenghong Xu. The Alginate lyase from Isoptericola halotolerans CGMCC 5336 as a new tool for the production of Alginate oligosaccharides with guluronic acid as reducing end.

Carbohydrate Research.Accept

41.Bobo Zhang, Hongbo Xing, Bingjie Jiang, Lei chen, Ganrong Xu, Yun Jiang, Dayong Zhang. Using millet as substrate for efficient production of monacolin K by solid-state fermentation of Monascus ruber.

Journal of Bioscience and Bioengineering.2018, 125, 333–338.

42.Toshihiko Kitajima, Yuanling Jia, Akiko Komatsuzaki, Cui Juan, Matsuzawa Fumiko, Aikawa Sei-Ichi, Gao Xiaodong, Chiba Yasunori. Structural modeling and mutagenesis of endo-Î⟡-N-acetylglucosaminidase from Ogataea minuta identifies the importance of Trp295 for hydrolytic activity.

Journal of Bioscience & Bioengineering.2018; 125; 168-174.

43.Min Jiang, Heng Li, Jinsong Shi, and Zhenghong Xu. Depolymerization konjac glucomannan: preparation and application in health care.

Journal of Zhejiang University-SCIENCE B.2018, 19 (7):505-514.

44.Zhu Jiang, Xueqin Lv, Yanfeng Liu, Hyun-dong Shin, Jianghua Li, Guocheng Du, and Long Liu. Biocatalytic Production of Glucosamine from N-acetylglucosamine by Diacetylchitobiose Deacetylase.

Journal of Microbiology and Biotechnology.DOI: 10.4014/jmb.1805.05061.

45.Zichao Wang, Libo Yang, Jianrong Wu, Hongtao Zhang, Li Zhu, and Xiaobei Zhan. Potential application of a low-viscosity and high-transparency xanthan gum produced fromXanthomonas campestrisCCTCC M2015714 in foods.

Preparative Biochemistry & Biotechnology.2018, 48(5):402-407.IF=1.26

46.Ying Liang, Li Zhu, Minjie Gao, Jianrong Wu, and Xiaobei Zhan. Effective production of biologically active water-soluble β-1,3-glucan by a coupled system of Agrobacterium sp. and Trichoderma harzianum.

Preparative Biochemistry & Biotechnology.2018, 48(5):446-456.

47.Diane Mutumwinka, ShenBao Zhao, Yishi Liu, Emmanuel Osei Mensah, Xiaodong Gao, and Morihisa Fujita. PiggyBac-based screening identified BEM4 as a suppressor to rescue growth defects in och1-disrupted yeast cells.

Bioscience Biotechnology Biochemistry.2018, 82(9): 1497-1507.

48.Ye Baotong, Cai Zhi, Wu Jing, Lin Xin, Chen Jingxiao, and Chen Jinghua. Preparation of Sulfonated Galactose-based Glycopolymers and Interactions with Lectins.

Acta Polymerica Sinica.2018, 4: 490-498.

综述

49.Zhen Kang, Zhengxiong Zhou, Yang Wang, Hao Huang, Guocheng Du, and Jian Chen. Bio-Based Strategies for Producing Glycosaminoglycans and Their Oligosaccharides.

Trends in Biotechnology.2018. 36: 806-818.

50.Guocheng Du, and Long Liu. Advances and prospects of Bacillus subtilis cellular factories: From rational design to industrial applications

Metabolic Engineering.https://doi.org/10.1016/j.ymben.2018.05.006.

51.Ning Wang, Shengtao Li, Tiantian Lu, Hideki Nakanishi, and Xiaodong Gao. Approaches towards the core pentasaccharide in N-linked glycans.

Chinese Chemical Letters.2018, 29: 35-39.

52.Zhifang Zhou, Han Lin, Chen Li, and Zhimeng Wu. Recent progress of fully synthetic carbohydrate-based vaccine using TLR agonist as build-in adjuvant.

Chinese Chemical Letters.2018, 29:19-26.

代表性研究论文

方向一：

1.Shengtao Li, Tiantian Lu, Xinxin Xu, Yi Ding, Zijie Li, Toshihiko Kitajima, Neta Dean, Ning Wang, Xiao-Dong Gao.Reconstitution of the lipid-linked oligosaccharide pathway for assembly of high-mannose N-glycans.Nature Communications.2019, 10: 1813.

2.Shini Feng, Huijie Zhang, Sha Xu, Chunyi Zhi, Hideki Nakanishi, Xiao-Dong Gao. Folate-conjugated, mesoporous silica functionalized boron nitride nanospheres for targeted delivery of doxorubicin.Materials Science & Engineering C-Materials for Biological Applications.2019, 96: 552-560. Xinxin Xu, ShengtaoLi, Ning Wang, Toshihiko Kitajima, Takehiko Yoko-o, Morihisa Fujita, Hideki Nakanishi, Xiao-Dong Gao. Structural and functional analysis of Alg1 beta-1,4 mannosyltransferase reveals the physiological importance of its membrane topology.Glycobiology.2019, 28(10): 741-753.

3.Aimin Li, Shenglin Duan, Yanting Dang, Xi Zhang, Kai Xia, Shiwei Liu, Xiaofeng Han, Jian Wen, Zijie Li, Xi Wang, Jia Liu, Peng Yuan, Xiao-Dong Gao.Origin identification of Chinese Maca using electronic nose coupled with GC-MS.Scientific Reports.2019, 9: 12216.

4.Shenbao Zhao, Yasuyuki Suda, Hideki Nakanishi, Ning Wang, Takehiko Yoko-o, Xiao-Dong Gao, Morihisa Fujita. Yeast Dop1 is required for glycosyltransferase retrieval from the trans-Golgi network.Biochimica et Biophysica Acta-General Subjects.2019, 1863(6): 1147-1157.

5.Kankai Shao, Qin Wang, Ning Wang, Xiao-Dong Gao, Hideki Nakanishi. Construction of functional chimeras of syntaxin-1A and its yeast orthologue, and their application to the yeast cell -based assay for botulinum neurotoxin serotype C.Biochimica et Biophysica Acta-General Subjects.2019, 1863(11): UNSP 129396.

6.Xiaoxiao Liu, Zijie Li, Zhou Chen, Ning Wang, Yahui Gao, Hideki Nakanishi, Xiao-Dong Gao. Production of L-Ribulose Using an Encapsulated L-Arabinose Isomerase in Yeast Spores.Journal of Agricultural and Food Chemistry.2019, 67(17): 4868-4875.

7.Sha Xu, Yu Zhang, Youran Li, Xiaole Xia, Jingwen Zhou, Guiyang Shi. Production of L-tyrosine using tyrosine phenol-lyase by whole cell biotransformation approach.Enzyme and Microbial Technology. 2019, 131, 109430.

8.Weiwei Ren, Zecheng Jin, Weijie Dong, Kitajima T, Xiao-Dong Gao, Fujita Morihisa. Glycoengineering of HEK293 cells to produce high-mannose-type N-glycan structures.Jounal of Biochemistry.2019, 166(3): 245-258.

9.Osei Mensah Emmanuel, XinYu Guo, Xiao-Dong Gao, Morihisa Fujita. Establishment of DHFR-deficient HEK293 cells for high yield of therapeutic glycoproteins.Journal of Bioscience and Bioengineering.2019, 128(4): 487-494.

10.Fujita Morihisa.Structural Remodeling and Shedding of GPI-Anchors.Trends in Glycoscience and Glycotechnology.2019, 181(31): SE71-SE73.

方向二

11.Haofei Hong, Zhifang Zhou, Kun Zhou, Shaozhong Liu，Zhongwu Guo, Zhimeng Wu.Site-specific C-terminal dinitrophenylation to reconstitute the antibody Fc functions for nanobodies.Chemical Science. 2019,10, 9331-9338.

12.Tingting Meng, Jing Han, Pengfei Zhang, Jing Hu, Junjie Fu, Jian Yin. Introduction of the alpha-ketoamide structure: en route to develop hydrogen peroxide responsive prodrugs.Chemical Science. 2019, 10(30): 7156-7162.

13.Jia Li, Wenhao Bao, Zhaocheng Tang, Baodang Guo, Shiwei Zhang, Haili Liu, Shuping Huang, Yan Zhang, Yijian Rao. Cercosporin-Bioinspired Selective Photooxidation Reactions under Mild Conditions.Green Chemistry.2019, 21, 6073-6081.

14.Yuning Han, Bin Hu, Mingyu Wang, Yang Yang, Li Zhang, Juan Zhou, Jinghua Chen. pH-Sensitive Tumor-Targeted Hyperbranched System Based on Glycogen Nano-particles for Liver Cancer Therapy.Applied Materials Today. 2019, doi.org/10.1016/j.apmt.2019.100521 IF8.013

15.Zhaocheng Tang, Jia Li, Fulin Lin, Wenhao Bao, Shiwei Zhang, Baodang Guo, Shuping Huang, Yan Zhang, Yijian Rao. Cercosporin-bioinspired photoreductive activation of aryl halides under mild conditions.Journal of Catalysis. 2019, 380: 1-8.

16.Shuqin Xu, Shuyu Zhou, Baoliang Mao, Jinghua Chen, Ziyin Zhang. Cornea-stroma-mimicking films derived from cellulose nanocrystal templating fibrous collagen as therapeutic contact lenses.ACS Sustainable Chemistry Engineering. 2019, 7 (14): 12248-12260.

17.Junjie Fu, Jing Han, Tingting Meng, Jing Hu, Jian Yin. Novel α-ketoamide based diazeniumdiolates as hydrogen peroxide responsive nitric oxide donors with anti-lung cancer activity.Chemical Communications. 2019, 55(86): 12904-12907.

18.Sha Zhu, Xiaoying Wang, Cheng Jing, Yongmei Yin, Nandi Zhou. A colorimetric ATP assay based on the use of a magnesium(II)-dependent DNAzyme.Microchimica Acta.2019, 186: 176.

19.Rongfeng Cai, Fan Yin, Zhongwen Zhang, Yaping Tian, and Nandi Zhou. Functional chimera aptamer and molecular beacon based fluorescent detection of Staphylococcus aureus with strand displacement-target recycling amplification.Analytica Chimica Acta.2019, 1075: 128-136.

20.Yaling Wu, Zheng Xu, Wenjing Sun, Yingyue Yang, Hui Jin, Lipeng Qiu, Jinghua Chen, and Jingxiao Chen. Co-responsive smart cyclodextrin-gated mesoporous silica nanoparticles with ligand-receptor engagement for anti-cancer treatment.Materials Science & Engineering C. 2019, 103: 109831.

21.Huiyan Ying, Juan Zhou, Mingyu Wang, Dandan Su, Qiaoqiao Ma, Guozhong Lv and Jinghua Chen. In Situ Formed Collagen-Hyaluronic Acid Hydrogel as Biomimetic Dressing for Promoting Spontaneous Wound Healing.Materials Science and Engineering: C. 2019, 101: 487-498.

22.Kamel S. Ahmed, Xiaotian Shan, Jing Mao, Lipeng Qiu, Jinghua Chen.Derma roller microneedles-mediated transdermal delivery of doxorubicin and celecoxib co-loaded liposomes for enhancing the anticancer effect.Materials Science & Engineering C. 2019, 99: 1448-1458.

23.Liang-Hua Zou, Hao Zhu, Shuai Zhu, Kai Shi, Cheng Yan, and Ping-Gui Li. Copper-Catalyzed Ring-Opening/Reconstruction of Anthranils with Oxo-Compounds: Synthesis of Quinoline Derivatives.Journal of Organic Chemistry. 2019, 84: 12301-12313.

24.Dandan Su, Juan Zhou, Kamel S.Ahmed, Qiaoqiao Ma, Guozhong Lv, Jinghua Chen. Fabrication and characterization of collagen-heparin-polypyrrole composite conductive film for neural scaffold.International Journal of Biological Macromolecules. 2019, 129: 895-903.

25.Shuqin Xu, Meiling Qiu, Quan Zhang, Jing Wu, Xiang Huimin, Jinghua Chen. Chain structure and immunomodulatory activity of fructosylated chondroitin from an engineeredEscherichia coliK4.International Journal of Biological Macromolecules. 2019, 133: 702-711.

26.Yaling Wang, Xingming Ji, Meilin Yan, Xue Chen, Mingzhu Kang, Liping Teng, Xiaotao Wu, Jinghua Chen, Chao Deng.Protective effect and mechanism of polysacchardie fromDictyophora indusiataon dextran sodium sulfate-induced colitis C57BL/6 mice.International Journal of Biological Macromolecules. 2019, 140: 973-984.

27.Yaling Wang, Li Lai, Liping Teng, Yuhong Li, Jiangqing Cheng, Jinghua Chen, Chao Deng.Mechanism of the anti-inflammatory activity by a polysaccharide fromDictyophora indusiatain lipopolysaccharide-stimulated macrophages.International Journal of Biological Macromolecules. 2019, 126: 1158-1166.

28.Yan Zhang, Yuan Cao, Liushen Lu, Shiwei Zhang, Wenhao Bao, Shuping Huang, Yijian Rao. Perylenequinonoid-Catalyzed [4 + 1] and [4 + 2] Annulations of Azoalkenes: Photocatalytic Access to 1,2,3-Thiadiazole/1,4,5,6-Tetrahydropyridazine Derivatives .Journal of Organic Chemistry.2019, 84(12): 7711-7721.

29.Huijie Zhang, Li Lai, Yalin Wang, Baoting Ye, Shuhao Deng, Airan Ding, Liping Teng, Lipeng Qiu, Jinghua Chen. Silk fibroin for CpG oligodeoxynucleotides delivery.ACS Biomaterials Science & Engineering. 2019, DOI: 10.1021/acsbiomaterials.9b01413.

30.Juan Zhou, Mingyu Wang, Huiyan Ying, Dandan Su, Huijie Zhang, Guozhong Lv and Jinghua Chen. Extracellular Matrix Component Shelled Nanoparticles as Dual Enzyme-Responsive Drug Delivery Vehicles for Cancer Therapy.ACS Biomaterials Science & Engineering.2018, 4: 2404-2411.

31.Safia Naz, Mingyu Wang, Yuning Han, Bin Hu, Liping Teng, Juan Zhou, Huijie Zhang and Jinghua Chen. Enzyme Responsive Mesoporous Silica Nanoparticles for Tumor Cells and Mitochondria Multistage-Targeted Drug Delivery.International Journal of Nanomedicine. 2019, 13: 2533-2542.

32.Safia Naz, Muhammad Shamoon, Rui Wang, Li Zhang, Juan Zhou, Jinghua Chen. Advances in Therapeutic Implications of Inorganic Drug Delivery Nano-Platforms for Cancer.International Journal of Molecular Science. 2019, 20, 965-982.

33.Binbin Yao, Sha Zhu, Xinyu Xu, Ninghan Feng, Yaping Tian, Nandi Zhou. Ultrasensitive detection of the androgen receptor through the recognition of an androgen receptor response element and hybridization chain amplification.Analyst.2019, 144: 2179-2185.

34.Kai Zhao, Feng Tang, Wei Shi, Haofei Hong, Zhifang Zhou, Wei Huang, Zhimeng Wu.One-step immobilization and purification of genetic engineering CBD fusion EndoS on cellulose for antibodies Fc-glycan remodeling.Bioorganic Chemistry. 2019, 91.

35.Shiwei Zhang, Zhaocheng Tang, Wenhao Bao, Jia Li, Baodang Guo, Shuping Huang, Yan Zhang, Yijian Rao. Perylenequinonoid-catalyzed photoredox activation for the direct arylation of (het)arenes with sunlight Electronic supplementary information (ESI) available.Organic & Biomolecular Chemistry. 2019, 17(17):4364-4369.

36.Jia Li, Wenhao Bao, Yan Zhang, Yijian Rao. Cercosporin-photocatalyzed sp3 (C-H) Activation for the Synthesis of Pyrrolo[3,4-c]quinolones.Organic & Biomolecular Chemistry.2019, 17(40): 8958-8962.

37.Ping-Gui Li, Hao Zhu, Min Fan, Cheng Yan, Kai Shi, Xi-Wen Chi, Liang-Hua Zou. Copper-catalyzed coupling of anthranils andα-keto acids: direct synthesis of α-ketoamides.Organic and Biomolecular Chem.istry. 2019, 17: 5902-5907.

38.Shengtao Wang, Jingtao Li, Zhou Ye, Jieling Li, Anhe Wang, Jing Hu, Shuo Bai, Jian Yin. Self-assembly of photosensitive and chemotherapeutic drugs for combined photodynamic-chemo cancer therapy with real-time tracing property.Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2019, 574: 44-51.

39.Zhou Ye, Dong Hua, Yijian Rao, Shuo Bai, Peter H. Seeberger, Jian Yin, Jing Hu. Targeted photodynamic therapy with a novel photosensitizer cercosporin encapsulated multifunctional copolymer.Colloids and Surfaces A: Physicochemical and Engineering Aspects.doi.org/10.1016/j.colsurfa.2019.124136.

40.Di Wang, Meiyue Wang, Anhe Wang, Jieling Li, Xin Li, Honglei Jian, Shuo Bai, Jian Yin. Preparation of collagen/chitosan microspheres for 3D macrophage proliferation in vitro.Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2019, 572: 266-273.

41.Ahmed Kamel S，Hussein Saied A，Ali Abdelmoneim H，Korma Sameh A, Lipeng Qiu, Jinghua Chen. Liposome: composition, characterisation, preparation, and recent innovation in clinical applications.Journal of Drug Targeting. 2019, 27(7): 742-761.

42.Jia Li, Wen-Hao Bao, Yan Zhang, Yijian Rao. Cercosporin-photocatalyzed C-S Coupling for the Selective Synthesis of Aryl Sulfides under Mild Conditions.European Journal of Organic Chemistry. 2019, DOI: 10.1002/ejoc.201901444.

43.Yijun Wang, Shuai Zhu, Liang-Hua Zou. Recent Advances in Direct Functionalization of Quinones.European Journal of Organic Chemistry. 2019, 2179-2201.

44.Liang-Hua Zou, Cheng Yan, Kai Shi,Liang Su, Shuai Zhu, Zhe-Kang Jia, and Qiuan Wang. Copper-Catalyzed C–C Bond Cleavage/Double Cyclization of α-Ketoamides with o-Phenylene Diamines: Synthesis of Benzimidazo[1,2-c]quinazolin-6-ones.European Journal of Organic Chemistry. 2019, DOI: 10.1002/ejoc.201901642.

45.Haofei Hong, Xinrui Zhao, Zhimeng Wu. A two-stage glycine supplementation strategy enhances the extracellular expression of Sortase A inEscherichia coli.Process Biochemistry.2019, 76, 11-17.

46.Ying Ou, Xin Jin, Jing Liu, Yaping Tian, Nandi Zhou. Visual detection of kanamycin with DNA-functionalized gold nanoparticles probe in aptamer-based strip biosensor.Analytical Biochemistry.2019, 587: 113432.

47.Xiaotian Shan, Jing Mao, Miaomiao Long, Kamel S. Ahmed, Changling Sun, Lipeng Qiu, Jinghua Chen.Influence of polyethylene glycol molecular weight on the anticancer drug delivery of pH-sensitive polymeric micelle.Applied Polymer. 2019, 136(32): 47854-47861.

48.Xiaopeng Zou, Chunjun Qin, Jing Hu, Junjie Fu, Guangzong Tian, Oren Moscovitz, Peter H.Seeberger, Jian Yin. Total Synthesis of_D-Glycero-_D-mannno-heptose 1β,7-Bisphosphate with 3-O-Amyl Amine Linker and Its Monophosphate Derivative.Chinese Journal of Natural Medicines.Accepted.

49.Jing Hu, Yong Xiao, Shu'an Shao, Rui Gu, Qimin Shi, Zhonghua Liu, Jian Yin. Construction and application of carbohydrate microarrays to detect foodborne bacteria.Chinese Journal of Natural Medicines. Accepted

50.Chen Li, Shijie Dai, Aijie Cao, Zhifang Zhou, Zhimeng Wu. Design and synthesis of rhamnose-modified exenatide conjugate by sortase A-mediated ligation.Journal of Carbohydrate Chemistry. 2019, 38(3): 167-178.

51.Qingquan Han, Yang Chen, Wei Song, Milin Zhang, Shengtao Wang, Peng Ren, Linna Hao, Anhe Wang, Shuo Bai, Jian Yin. Fabrication of agarose hydrogel with patterned silver nanowires for motion sensor.Bio-Design and Manufacturing. 2019, doi.org/10.1007/s42242-019-00051-w.

方向三

52.Yanfeng Liu, Long Liu, Jianghua Li, Guocheng Du, Jian Chen. Synthetic Biology Toolbox and Chassis Development inBacillus subtilis.Trends in Biotechnology. 2019, 37(5): 548-562.

53.Xiaolong Zhang, Yanfeng Liu, Long Liu, Jianghua Li, Guocheng Du, Jian Chen. Microbial production of sialic acid and sialylated human milk oligosaccharides: Advances and perspectives.Biotechnology Advances. 2019, 37: 787-900.

54.Yaokang Wu, Taichi Chen, Yanfeng Liu, Rongzhen Tian, Xueqin Lv,Jianghua Li, Guocheng Du, Jian Chen, Rodrigo Ledesma-Amaro, Long Liu.Design of a programmable biosensor-CRISPRi geneticcircuits for dynamic and autonomous dual-control ofmetabolic flux inBacillus subtilis.Nucleic Acids Research. 2019, Accepeted.

55.Yang Gu, Xueqin Lv, Yanfeng Liu, Jianghua Li, Guocheng Du, Jian Chen, Rodrigo Ledesma-Amaro, Long Liu. Synthetic redesign of central carbon and redox metabolism for high yield production of N-acetylglucosamine inBacillus subtilis.Metabolic Engineering. 2019, 51: 59-69.

56.Jieying Deng, Chunmei Chen, Yang Gu, Xueqin Lv, Yanfeng Liu, Jianghua Li, Rodrigo Ledesma-Amaro, Guocheng Du, Long Liu. Creating an in vivo bifunctional gene expression circuit through an aptamer-based regulatory mechanism for dynamic metabolic engineering inBacillus subtilis.Metabolic Engineering. 2019, 55: 179-190.

57.Rongzhen Tian, Yanfeng Liu, Chen, JR; Jianghua Li, Long Liu, Guocheng Du, Jian Chen. Synthetic N-terminal coding sequences for fine-tuning gene expression and metabolic engineering inBacillus subtilis.Metabolic Engineering. 2019, 55: 131-141.

58.Hao Wang, Lin Zhang, Weijiao Zhang, Yang Wang, Jianghua Li, Guocheng Du, Zhen Kang. Secretory expression of biologically active chondroitinase ABC I for production of chondroitin sulfate oligosaccharides.Carbohydrate Polymers. 2019, 224, 115135.

59.Shixiu Cui, Xueqin Lv, Yaokang Wu, Jianghua Li, Guocheng Du, Rodrigo Ledesma-Amaro, Long Liu. Engineering a Bifunctional Phr60-Rap60-Spo0A Quorum-Sensing Molecular Switch for Dynamic Fine-Tuning of Menaquinone-7 Synthesis inBacillus subtilis.ACS Synthetic Biology. 2019, 8: 1826-1837.

60.Jieying Deng, Liuyan Gu, Taichi Chen, Hao Huang, Xiaoqiang Yin, Xueqin Lv, Yanfeng Liu, Nan Li, Zhenmin Liu, Jianghua Li, Guocheng Du, Long Liu. Engineering the Substrate Transport and Cofactor Regeneration Systems for Enhancing 2′-Fucosyllactose Synthesis inBacillus subtilis.ACS Synthetic Biology. 2019, 8: 2418-2427.

61.Xiaomin Dong, Nan Li, Zhenmin Liu, Xueqin Lv, Jianghua Li, Guocheng Du, Miao Wang, Long Liu. Modular pathway engineering of key precursor supply pathways for lacto‑N‑neotetraose production inBacillus subtilis.Biotechnology for Biofuels. 2019, 12: 212.

62.Wenlong Ma, Yanfeng Liu, Xueqin Lv, Jianghua Li, Guocheng Du, Long Liu. Combinatorial pathway enzyme engineering and host engineering overcomes pyruvate overflow and enhances overproduction of N-acetylglucosamine inBacillus subtilis.Microbial Cell Factories. 2019, 18: 1.

63.Chen Deng, Xueqin Lv, Jianghua Li, Yanfeng Liu, Guocheng Du, Rodrigo Ledesma-Amaro, Long Liu. Synthetic repetitive extragenic palindromic (REP) sequence as an efficient mRNA stabilizer for protein production and metabolic engineering in prokaryotic cells.Biotechnology and Bioengineering. 2019, 116: 5-18.

64.Jiang, Z; Tengfei Niu, Xueqin Lv, Yanfeng Liu, Jianghua Li, Lu, W; Guocheng Du, Jian Chen, Long Liu. Secretory Expression Fine-Tuning and Directed Evolution of Diacetylchitobiose Deacetylase byBacillus subtilis.Applied and Environmental Microbiology. 2019, 85(17): e01076-19.

65.Haiquan Yang, Jinyuan Hu, Xiao Lu, Fuxiang Wang, Wei Shen, Wei Hu, Lingling Wang, Xianzhong Chen, Long Liu. Improving extracellular protein production inEscherichia coliby overexpressing D,D-carboxypeptidase to perturb peptidoglycan network synthesis and structure.Applied Microbiology and Biotechnology.2019, 103(2): 793-806.

66.Wei Hu, Wenjian Li, Haiquan Yang, Jihong Chen. Current strategies and future prospects for enhancing microbial production of citric acid.Applied Microbiology and Biotechnology.2019, 103(1): 201-209.

67.Haiquan Yang, Yuxiang Xue, Cui Yang, Wei Shen, You Fan, and Xianzhong Chen. Modular engineering of tyrosol production inEscherichia coli.Journal of Agricultural and Food Chemistry. 2019, 67: 3900-3908.

68.Yang Wang, Qingtao Liu, Huanjiao Weng, Shi, YA; Jian Chen, Guocheng Du, Zhen Kang. Construction of Synthetic Promoters by Assembling the Sigma Factor Binding-35 and-10 Boxes.Biotechnology Journal. 2019, 14, 1800298.

69.Lin Zhao, Rongzhen Tian, Qingyang Shen, Yanfeng Liu, Long Liu, Jianghua Li, Guocheng Du. Pathway Engineering ofBacillus subtilisfor Enhanced N-Acetylneuraminic Acid Production via Whole-Cell Biocatalysis.Biotechnology Journal. 2019, 14, 1800682.

70.Mengyan Pan, Jianghua Li, Xueqin Lv, Guocheng Du, Long Liu. Molecular engineering of chitinase fromBacillussp. DAU101 for enzymatic production of chitooligosaccharides.Enzyme and Microbial Technology. 2019, 124: 54-62.

71.Haiquan Yang, Fuxiang Wang, Haokun Wang, Xiao Lu, Wei Shen, Xianzhong Chen. DeletingmrdAandmrcBto significantly improve extracellular recombinant protein production inEscherichia coli.Biochemical Engineering Journal.2019, 143: 185-195.

72.Qingtao Liu, Xuerong Jin, Fang Fang, Jianghua Li, Guocheng Du, Zhen Kang. Food-grade expression of an iron-containing acid urease inBacillus subtilis.Journal of Biotechnology. 2019, 293: 66-71.

73.Yang Wang, Jian Chen, Zhen Kang. In Silico Protein Design Promotes the Rapid Evolution of Industrial Enzymes.Biochemistry. 2019, 58: 1451-1453.

74.Xing Zhou, Jing He, Li Wang, Yang Wang, Guocheng Du, Zhen Kang. Metabolic Engineering ofSaccharomyces cerevisiaeto Improve Glucan Biosynthesis.Journal of Microbiology and Biotechnology. 2019, 29(5): 758-764.

75.Haibo Yuan, Yanfeng Liu, Xueqin Lv, Jianghua Li, Guocheng Du, Zhongping Shi, Long Liu. Enhanced 2,5-Furandicarboxylic Acid (FDCA) Production inRaoultella ornithinolyticaBF60 by Manipulation of the Key Genes in FDCA Biosynthesis Pathway.Journal of Microbiology and Biotechnology.2019, 28 (12): 1999-2008.

76.Jinyuan Hu, Xiao Lu, Haokun Wang, Fuxiang Wang, Yuan Zhao, Wei Shen, Haiquan Yang, Xianzhong Chen. Enhancing extracellular protein production inEscherichia coliby deleting the D-alanyl-D-alanine carboxypeptidase genedacC.Engineering in Life Sciences. 2019, 19(4): 246-327.

77.Zhengxiong Zhou, Qing Li, Ruirui Xu, Bingbing Wang, Guocheng Du, Zhen Kang. Secretory expression of the rat aryl sulfotransferases IV with improved catalytic efficiency by molecular engineering.3 Biotech. 2019, 9: 246.

78.Nshimiyimana, P; Long Liu, Guocheng Du. Engineering of L-amino acid deaminases for the production ofα-keto acids from L-amino acids.Bioengineered. 2019, 10(1): 43-51.

79.Yang Fan, Chen Liangqiang, Liu Yanfeng, Li Jianghua, Li Wang, Chen Jian. Identification of microorganisms producing lactic acid during solid-state fermentation of Maotai flavour liquor.Journal of the Institute of Brewing. 2019, 125(1): 171-177.

80.Chen Deng, Xueqin Lv, Yanfeng Liu, Jianghua Li, Wei Lu, Guocheng Du, Long Liu. Metabolic engineering ofCorynebacterium glutamicumS9114 based on whole-genome sequencing for efficient N-acetylglucosamine synthesis.Synthetic and Systems Biotechnology. 2019, 4: 120-129.

方向四

81.Bobo Zhang, Yuyan Guan, Pengfei Hu, Lei Chen, Ganrong Xu, Liming Liu, Peter C.K. Cheung. Production of bioactive metabolites by submerged fermentation of the medicinal mushroom Antrodia cinnamomea: recent advances and future development.Critical Reviews in Biotechnology. 2019, 39: 541-554.

82.Lei Chen, Zhengqi Wang, Bobo Zhang, Mengdie Ge, Huisuan Ng, Yuge Niu, Liming Liu. Production, structure and morphology of exopolysaccharides yielded by submerged fermentation ofAntrodia cinnamomea.Carbohydrate Polymers. 2019, 205: 271-278.

83.Lei Chen, Mengdie Ge, Yujie Zhu, Yu Song, Peter C. K. Cheung, Bobo Zhang, Liming Liu. Structure, bioactivity and applications of natural hyperbranched polysaccharides.Carbohydrate Polymers. 2019, 223: 115076.

84.Chang Su, Jinsong Gong, Yuxin Sun, Jiufu Qin, Shen Zhai, Heng Li, Hui Li,Zhenming Lu, Zhenghong Xu, Jinsong Shi. Combining Pro-peptide Engineering and Multisite Saturation Mutagenesis to Improve the Catalytic Potential of Keratinase.ACS Synthetic Biology. 2019, 8(2), 425-433.

85.Kangle Wang, Zhenming Lu, Xiangjunzhi Mao, Lu Chen, Jinsong Gong, Yilin Ren, Yan Geng, Heng Li, Hongyu Xu, Guohua Xu, Jinsong Shi, Zhenghong Xu. Structural Characterization and Anti-alcoholic Liver Injury Activity of A Polysaccharide from Coriolus versicolor mycelia.International Journal of Biological Macromolecules. 2019, 137: 1102-1111.

86.Xun-Cheng Zong, Chuang Li, Yao-Hui Xu, Die Hu, Bo-Chun Hu, Jia Zang and Min-Chen Wu. Substantially improving the enantioconvergence of PvEH1, a Phaseolus vulgaris epoxide hydrolase, towards m-chlorostyrene oxide by laboratory evolution.Microbial Cell Factories. 2019,18: 202.

87.Chuang Li , Jun Zhao , Die Hu, Bo-Chun Hu, Rui Wang , Jia Zang , Min-Chen Wu. Multiple site-directed mutagenesis of a Phaseolus vulgaris epoxide hydrolase to improve its catalytic performance towards p-chlorostyrene oxide based on the computer-aided re-design.International Journal of Biological Macromolecules. 2019, 121: 326-332.

88.Chuang Li, Bo-Chun Hu, Die Hu, Xiong-Feng Xu, Xun-Cheng Zong, Jin-Ping Li, Min-Chen Wu. Stereoselective ring-opening of styrene oxide at elevated concentration by Phaseolus vulgaris epoxide hydrolase, PvEH2, in the organic/aqueous biphasic system.Catalysis Communications. 2019, 123: 1-5.

89.Yanjie Chunyu, Zhenming Lu, Zhishan Luo, Shuoshuo Li, Hui Li,Yan Geng, Hong-yu Xu, Zhenghong Xu, Jinsong Shi. Promotion of Metabolite Synthesis in Isaria cicadae, a Dominant Species in the Cicada Flower Microbiota, by Cicada Pupae.Journal of Agricultural and Food Chemistry. 2019, 67(31): 8476-8484.

90.Deqiang Zhu,Jianrong Wu,Xiaobei Zhan, Li Zhu, Yun Jiang. Enhanced N-acetyl-d-neuraminic production from glycerol and N-acetyl-_D-glucosamine by metabolically engineeredEscherichia coliwith a two-stage pH-shift control strategy.Journal of Industrial Microbiology & Biotechnology. 2019, 46(2): 125-132.

91.Chuang Li, Ting-Ting Kan, Die Hu, Ting-Ting Wang, Yong-Jun Su, Chen Zhang, Jian-Qing Cheng, Min-Chen Wu. Improving the activity and enantioselectivity of PvEH1, a Phaseolus vulgaris epoxide hydrolase, for o-methylphenyl glycidyl ether by multiple sitedirected mutagenesis on the basis of rational design.Molecular Catalysis. 2019, 476, 110517.

92.Haijuan Hou, Jinsong Gong, Yuxiu Dong, Jiufu Qin, Heng Li, Hui Li, Zhenming Lu, Xiaomei Zhang, Zhenghong Xu, Jinsong Shi. Phospholipase D Engineering for Improving the Biocatalytic Synthesis of Phosphatidylserine.Bioprocess and Biosystems Engineering. 2019, (4): 1-10.

93.Jianrong Wu, Jingbo Zhang, Hongtao Zhang, Minjie Gao, Liming Liu, Xiaobei Zhan.Recycling of cooking oil fume condensate as a substrate for rhamnolipids production of byPseudomonas aeruginosaWB505.Bioprocess and Biosystem Engineering.2019, 42(5): 777-784.

代表性学术论文

方向一：

1.Yicheng Wang, Yusuke Maeda, Yi-Shi Liu, Yoko Takada, Akinori Ninomiya, Tetsuya Hirata, Morihisa Fujita, Yoshiko Murakami, and Taroh Kinoshita.Cross-talks of glycosylphosphatidylinositol biosynthesis with glycosphingolipid biosynthesis and ER-associated degradation.Nature Communications. 2020, 11(1): 860.

2.Rongfeng Cai, Zhongwen Zhang, Haohan Chen, Yaping Tian, Nandi Zhou. A versatile signal-on electrochemical biosensor forStaphylococcus aureusbased on triple-helix molecular switch.Sensors and Actuators B: Chemical.2020, 326: 128842.

3.Rongfeng Cai, Fan Yin, Haohan Chen, Yaping Tian, Nandi Zhou. A fluorescent aptasensor forStaphylococcus aureusbased on strand displacement amplification and self-assembled DNA hexagonal structure.Microchimica Acta. 2020, 187: 304.

4.Hao Wei, Rongfeng Cai, Hui Yue, Yaping Tian, Nandi Zhou. Screening and application of a truncated aptamer for high-sensitive fluorescent detection of metronidazole.Analytica Chimica Acta.2020, 1128: 203-210.

5.Xiaoman Zhou, Ganglong Yang, Feng Guan. Biological Functions and Analytical Strategies of Sialic Acids in Tumor.Cells. 2020, 9(2): 273.

6.Yi-Shi Liu, Morihisa Fujita. Mammalian GPI-anchor modifications and the enzymes involved.Biochemical Society Transactions. 2020, 48(3): 1129-1138.

7.Mostafa Basiony, Yan Yang, Guoyu Liu, Xiao-Dong Gao, Hideki Nakanishi. Studies on the Properties of the Sporulation Specific Protein Dit1 and its Product Formyl Tyrosine.Journal of Fungi. 2020, 6(2): 77.

8.Xin-Yu Guo, Yi-Shi Liu, Xiao-Dong Gao, Taroh Kinoshita, Morihisa Fujita. Calnexin mediates the maturation of GPI-anchors through ER retention.Journal of Biological Chemistry. 2020, doi:10.1074/jbc.RA120.015577.

9.Gun-Hee Lee, Morihisa Fujita, Hideki Nakanishi, Haruhiko Miyata, Masahito Ikawa, Yusuke Maeda, Yoshiko Murakami, and Taroh Kinoshita.PGAP6, a GPI-specific phospholipase A2, has narrow substrate specificity against GPI-anchored proteins.Journal of Biological Chemistry. 2020, 295(42): 14501-14509.

10.Zijie Li, Fen Li, Li Cai, Zhou Chen, Ling Qin, Xiao-Dong Gao. One-pot multienzyme synthesis of rare ketoses from glycerol.Journal of Agricultural and Food Chemistry. 2020, 68(5): 1347.

11.Zijie Li, Xiaoxiao Liu, Hideki Nakanishi, Xiao-Dong Gao. Encapsulation of mannose-6-phosphate isomerase in yeast spores and its application in L-ribose production.Journal of Agricultural and Food Chemistry. 2020, 68(25): 6892.

12.Wenyan Chen, Rong Wang, Dan Li, Chenyang Zuo, Piaopiao Wen, Haili Liu, Yongquan Chen, Morihisa Fujita, Zhimeng Wu, Ganglong Yang. Comprehensive analysis of the glycome and glycoproteome of bovine milk-derived exosomes.Journal of Agricultural and Food Chemistry. 2020, doi:10.1021/acs.jafc.0c04605J.

13.Qiang Chao, Yi Ding, Zheng-Hui Chen, Meng-Hai Xiang, Ning Wang, Xiao-Dong Gao. Recent Progress in Chemo-Enzymatic Methods for the Synthesis of N-Glycans.Frontiers in Chemistry. 2020, 8: 513.

14.Ying Ou, Xin Jin, Jingwen Fang, Yaping Tian, Nandi Zhou. Multi-cycle signal-amplified colorimetric detection of tobramycin based on dual-strand displacement and three-way DNA junction.Microchemical Journal.2020, 156: 104823.

15.Zhou Chen, Zijie Li, Fen Li, Mayan Wang, Ning Wang, Xiao-Dong Gao. Cascade synthesis of rare ketoses by whole cells based on L-rhamnulose-1-phosphate aldolase.Enzyme and Microbial Technology. 2020, 133: 109456.

16.Kankai Shao, Feng Li, Yan Yang, Ning Wang, Xiao-Dong Gao, Hideki Nakanishi. Characteristics of SNARE proteins are defined by distinctive properties of SNARE motifs.Biochem Biophys Acta Gen Subjects. 2020, 186: 129658.

17.Yifan Jin, Michiyo Okamoto, Hiroji Chibana, Guoyu Liu, Xiao-Dong Gao, Hideki Nakanishi. Functional characteristics of Svl3 and Pam1 that are required for proper cell wall formation in yeast cells.Yeast. 2020, 37: 359-371.

18.Zhou Chen, Zijie Li, Fen Li, Ning Wang, Xiao-Dong Gao. Characterization of alditol oxidase fromStreptomyces coelicolorand its application in the production of rare sugars.Bioorganic＆Medicinal Chemistry. 2020, 28 (10): 115464.

19.Yi-Shi Liu, Matabaro Emmanuel, Xiao-Dong Gao, Morihisa Fujita. Selecting cells expressing high levels of recombinant proteins using the GPI-anchored protein with selenocysteine system.Journal of Bioscience and Bioengineering. 2020,doi:10.1016/j.jbiosc.2020.10.004.

20.Cheng Jing, Haohan Chen, Rongfeng Cai, Yaping Tian, Nandi Zhou. An electrochemical aptasensor for ATP based on a configuration-switchable tetrahedral DNA nanostructure.Analytical Methods.2020, 12: 3285-3289.

21.Ji-Xiang Jia, NdayambajeYvan Kalisa, Tian-Tian Lu, Zhifang Zhou, Xiao-Dong Gao, Ning Wang. Chemo-enzymatic synthesis of the ALG1-CDG biomarker and evaluation of its immunogenicity.Bioorganic＆Medicinal Chemistry Letters. 2020, 30: 127614.

22.Shen-Bao Zhao, Neta Dean, Xiao-Dong Gao, Morihisa Fujita.MON2 Guides Wntless Transport to the Golgi through Recycling Endosomes.Cell Structure and Function. 2020, 45(1): 77-92.

23.Dehua Liu, Dawei Zhang, Qinqin Huang, Lili Gu, Nandi Zhou, Yaping Tian. Mutagenesis for improvement of activity and stability of prolyl aminopeptidase fromAspergillus oryzae.Applied Biochemistry and Biotechnology.2020, 191: 1483-1498.

24.Ran Cao, Tian-Chan Zhang, Ya-Ran Chen, Cui Cao, Huan Chen, Yi-Fan Huang, Morihisa Fujita,Li Liu, Josef Voglmeir.Aberration of Serum and Tissue N-Glycans in Mouse β1,4-GalT1 Y286L Mutant Variants.Glycoconjugate Journal. 2020, doi: 10.1007/s10719-020-09946-8.

25.Feng Li, Ganglong Yang, Tachikawa H., Kankai Shao, Yan Yang, Xiao-Dong Gao, Hideki Nakanishi. Identification of novel O-GlcNAc transferase substrates using yeast cells expressing OGT.Journal of Generaland Applied Microbiology. 2020, In press.

26.Guoyu Liu, Xiao-Dong Gao, Hideki Nakanishi. Unique properties of theS. cerevisiaespore wall and its applications.Trends in Glycoscience Glycotechnology. 2020, In press.

27.金则成,喜多岛敏彦,藤田盛久,高晓冬.哺乳动物细胞中糖链结构的改造.《食品与生物技术学报》. 2020, 2: 39-46.

方向二：

28.Jun Hu, Wenrui Wu, Yufei Qin, Chao Liu, Peng Wei, Jing Hu, Peter H. Seeberger, Jian Yin. Fabrication of glyco-metal-organic frameworks for targeted interventional photodynamic/chemotherapy for hepatocellular carcinoma through percutaneous transperitoneal puncture.Advanced Functional Materials. 2020, 30(19): 1910084.

29.Juntao Cai, Jing Hu, Chunjun Qin, Lingxin Li, Dacheng Shen, Guangzong Tian, Xiaopeng Zou, Peter H. Seeberger, Jian Yin. Chemical synthesis elucidates the key antigenic epitope of the autism-related bacteriumClostridium bolteaecapsular octadecasaccharide.Angewandte Chemie International Edition. 2020, doi:10.1002/anie.202007209.

30.Guangzong Tian, Jing Hu, Chunjun Qin, Lingxin Li, Xiaopeng Zou, Juntao Cai, Peter H. Seeberger, Jian Yin. Chemical synthesis and immunological evaluation of Helicobacter pylori serotype O6 tridecasaccharide O-antigen containing a unique DD-heptoglycan.Angewandte Chemie International Edition. 2020, 59(32): 13362-13370.

31.Juan Zhou, Yuning Han, Yang Yang, Li Zhang, Hong Wang, Yiting Shen, Jiahui Lai, and Jinghua Chen. Phospholipid-Decorated Glycogen Nanoparticles for Stimuli-Responsive Drug Release and Synergetic Chemophotothermal Therapy of Hepatocellular Carcinoma.ACS Applied Materials & Interfaces. 2020, 12: 23311.

32.Yuning Han, Bin Hu, Mingyu Wang, Yang Yang, Li Zhang, Juan Zhou, Jinghua Chen. pH-Sensitive Tumor-Targeted Hyperbranched System Based on Glycogen Nanoparticles for Liver Cancer Therapy.Applied Materials Today. 2020, 18: 100521.

33.Shijie Dai, Shaozhong Liu, Chen Li, Zhifang Zhou, Zhimeng Wu. Site-selective modification of exendin 4 with variable molecular weight dextrans by oxime-ligation chemistry for improving type 2 diabetic treatment.Carbohydrate Polymers. 2020, 249, 116864.

34.Xinyu Chen, Junjie Fu, Feng Zhou, Qimeng Yang, Jialing Wang, Hui Feng, Wen Jiang, Luofan Jin, Xuelin Tang, Neng Jiang, Jian Yin, Jing Han. Stapled and Xenopus Glucagon-Like Peptide 1 (GLP-1)-Based Dual GLP-1/Gastrin Receptor Agonists with Improved Metabolic Benefits in Rodent Models of Obesity and Diabetes.Journal of Medicinal Chemistry. 2020, doi:10.1021/acs.jmedchem.0c00736.

35.Han Lin, Haofei Hong, Jinfeng Wang, Chen Li, Zhifang Zhou, Zhimeng Wu. Rhamnose modified bovine serum albumin as a carrier protein promotes the immune response against sTn antigen.Chemical Communications. 2020, doi:10.1039/d0cc05263a.

36.Guangzong Tian, Chunjun Qin, Zhonghua Liu, Dacheng Shen, Xiaopeng Zou, Junjie Fu, Jing Hu, Peter H. Seeberger, Jian Yin. Total synthesis of the Helicobacter pylori serotype O2 O-antigenα-(1→2)- andα-(1→3)-linked oligoglucosides.Chemical Communications. 2020, 56(3): 344-347.

37.Jing Han, Junjie Fu, Qimeng Yang, Feng Zhou, Xinyu Chen, Chenglin Li, Jian Yin. Rational design and biological evaluation of gemfibrozil modified Xenopus GLP-1 derivatives as long-acting hypoglycemic agents.European Journal of Medicinal Chemistry. 2020, 198, 112389.

38.Zhou Ye, Dong Hua, Yijian Rao, Shuo Bai, Peter H. Seeberger, Jian Yin, Jing Hu. Targeted photodynamic therapy with a novel photosensitizer cercosporin encapsulated multifunctional copolymer.Colloids and Surfaces A-Physicochemical and Engineering Aspects. 2020, 585, 124136.

39.Ming Zhao, Chunjun Qin, Lingxin Li, Haotian Xie, Beining Ma, Ziru Zhou, Jian Yin, Jing Hu. Conjugation of synthetic trisaccharide ofStaphylococcus aureustype 8 capsular polysaccharide elicits antibodies recognizing intact bacterium.Frontiers in Chemistry. 2020, 8, 258.

40.Yishu Yan, Xiaoni Liu, Yichao Zhuang, Yanduo Zhai, Xiting Yang, Yang Yang, Shicong Wang, Fei Hong, Jinghua Chen. Pien Tze Huang accelerated wound healing by inhibition of abnormal fibroblast apoptosis in Streptozotocin induced diabetic mice.Journal of Ethnopharmacology. 2020, 261, 113203.

41.Haiquan Yang, Yingfang Ma, Yuan Zhao, Wei Shen, Xianzhong Chen. Systematic engineering of transport and transcription to boost alkaline α-amylase production inBacillus subtilis.Applied Microbiology and Biotechnology.2020, 104: 2973-2985.

42.Yang Yang, Yanyan Zhang, Yishu Yan, Qian Ji, Yutong Dai, Suyuan Jin, Yanxian Liu, Jinghua Chen, Liping Teng. A Sponge-Like Double-Layer Wound Dressing with Chitosan and Decellularized Bovine Amniotic Membrane for Promoting Diabetic Wound Healing.Polymers. 2020, 12(3): 535.

43.Peng Wei, Zhou Ye, Shuya Cao, Shuo Bai, Peter H. Seeberger, Jian Yin, Jing Hu. Combination therapy with amphotericin B and doxorubicin encapsulated in mannosylated nanomicelles for visceral leishmaniasis.Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2020, 598, 124804.

44.Yang Chen, Li Duan, Yuqi Ma, Qingquan Han, Xin Li, Jieling Li, Anhe Wang, Shuo Bai, Jian Yin. Preparation of transient electronic devices with silk fibroin film as a flexible substrate.Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2020, 600, 124896.

45.Yan Zhang, Jiangli Lou, Min Li, Zhenbo Yuan, Yijian Rao. Emodin as a novel organic photocatalyst for selective oxidation of sulfides under mild conditions.The Royal Society of Chemistry Advances.2020, 10, 19747-19750.

46.Dan Li, Surui Yao, Zhifang Zhou, Jie Shi, Zhaohui Huang, Zhimeng Wu. Hyaluronan decoration of milk exosomes directs tumor-specific delivery of doxorubicin.Carbohydrate Research. 2020, 493, 108032.

47.Yunzhan Ning, Chunjun Qin, Wenbin Sun, Junjie Fu, Jing Hu, Jian Yin. Anomeric configuration-dependence of the Lattrell-Dax epimerization from D-glucose to synthetically useful D-allose derivatives.Chinese Journal of Natural Medicines. 2020, 18(10): 723-728.

48.Xiaopeng Zou, Chunjun Qin, Jing Hu, Junjie Fu, Guangzong Tian, Oren Moscovitz, Peter H.Seeberger, Jian Yin. Total synthesis of D-glycero-D-mannno-heptose 1β,7-bisphosphate with 3-O-amyl amine linker and its monophosphate derivative.Chinese Journal of Natural Medicines. 2020, 18(8): 628-632.

49.Jing Hu, Yong Xiao, Shu’an Shao, Rui Gu, Qimin Shi, Zhonghua Liu, Jian Yin. Construction and application of carbohydrate microarrays to detect foodborne bacteria.Chinese Journal of Natural Medicines. 2020, 18(3): 214-220.

50.Philippe Icyishaka, Chenxing Li, Liushen Lu, Wenhao Bao, Jia Li, Yan Zhang, Yijian Rao. Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions.Journal of Visualized Experiments.2020, e60786, Page1-18.

51.Lipeng Feng, Jie Shi, Haofei Hong, Zhifang Zhou, Zhimeng Wu. GM3 trisaccharide biosynthesis and process optimization using engineeredE. colilysate and whole-cell catalysis.Journal of Carbohydrate Chemistry.2020, 39, 217-231.

52.Chunjun Qin, Zhonghua Liu, Meiru Ding, Juntao Cai, Junjie Fu, Jing Hu, Peter H. Seeberger, Jian Yin. Chemical synthesis of thePseudomonas aeruginosaO11 O-antigen trisaccharide based on neighboring electron-donating effect.Journal of Carbohydrate Chemistry. 2020, 39(08): 374-397.

方向三：

53.Xianhao Xu, Xueliang Li, Yanfeng Liu, Yonglian Zhu, Jianghua Li, Guocheng Du, Jian Chen, Rodrigo Ledesma-Amaro, Long Liu. Pyruvate-responsive genetic circuits for dynamic control of central metabolism.Nature Chemical Biology. 2020, 16, 1261-1268.

54.Rongzhen Tian, Yanfeng Liu, Yanting Cao，Zhongjie Zhang, Jianghua Li, Long Liu, Guocheng Du, Jian Chen. Titrating bacterial growth and chemical iosynthesis for efficient N-acetylglucosamine and N-acetylneuraminic acid bioproduction.Nature Communications. 2020, 11: 5078.

55.Yang Wang, Litao Hu, Hao Huang, Hao Wang, Tianmeng Zhang, Jian Chen, Guocheng Du, Zhen Kang. Eliminating the capsule-like layer to promote glucose uptake for hyaluronan production by engineeredCorynebacterium glutamicum.Nature Communications.2020, 11(1): 3120.

56.Xianhao Xu, Yanfeng Liu, Guocheng Du, Rodrigo Ledesma-Amaro, Long Liu. Microbial Chassis Development for Natural Product Biosynthesis.Trends in Biotechnology. 2020, 38(7): 779-796.

57.Xuerong Jin, Qing Li, Yang Wang, Weijiao Zhang, Ruirui Xu, Jianghua Li, Guocheng Du, Zhen Kang. Optimizing the sulfation-modification system for scale preparation of chondroitin sulfate A.Carbohydrate Polymers. 2020, 246: 116570.

58.Xueqin Lv, Yaokang Wu, Rongzhen Tian, Yang Gu, Yanfeng Liu, Jianghua Li, Guocheng Du, Rodrigo Ledesma-Amaro, Long Liu. Synthetic metabolic channel by functional membrane microdomains for compartmentalized flux control.Metabolic Engineering.2020, 59: 106-118.

59.Xueqin Lv, Cheng Zhang, Shixiu Cui, Xianhao Xu, Lingling Wang, Jianghua Li, Guocheng Du, Jian Chen, Rodrigo Ledesma-Amaro, Long Liu. Assembly of pathway enzymes by engineering functional membrane microdomain components for improved N-acetylglucosamine synthesis inBacillus subtilis.Metabolic Engineering. 2020, 61: ‏ 96-105.

60.Shixiu Cui, Hongzhi Xia, Taichi Chen, Yang Gu, Xueqin Lv, Yanfeng Liu, Jianghua Li, Guocheng Du, Long Liu. Cell Membrane and Electron Transfer Engineering for Improved Synthesis of Menaquinone-7 inBacillus subtilis.iScience. 2020, 23(3): 100918.

61.Yaokang Wu, Yanfeng Liu, Xueqin Lv, Jianghua Li, Guocheng Du, Long Liu. Applications of CRISPR in a Microbial Cell Factory: From Genome Reconstruction to Metabolic Network Reprogramming.ACS Synthetic Biology. 2020, 9(9): 2228-2238.

62.Yaokang Wu, Yanfeng Liu, Xueqin Lv, Jianghua Li, Guocheng Du, Long Liu. Applications of CRISPR in microbial cell factory: From genome re-construction to metabolic network re-programming.ACS Synthetic Biology. 2020, 9(9): ‏2228-2238.

63.Yunfeng Zhang, Qixing Liang, Chuanzhi Zhang, Juan Zhang, Guocheng Du, Zhen Kang. Improving production ofStreptomyces griseustrypsin for enzymatic processing of insulin precursor.Microbial Cell Factories.2020, 19 (1): 88.

64.Xiaomin Dong, Nan Li, Zhenmin Liu, Xueqin Lv, Yu Shen, Jianghua Li, Guocheng Du, Miao Wang, Long Liu. CRISPRi-Guided Multiplexed Fine-Tuning of Metabolic Flux for Enhanced Lacto-N-neotetraose Production inBacillus subtilis.Journal of Agricultural and Food Chemistry. 2020, 68(8): 2477-2484.

65.Han Yang, Yanfeng Liu, Jianghua Li, Long Liu, Guocheng Du, Jian Chen. Systems metabolic engineering ofBacillus subtilisfor efficient biosynthesis of 5-methyltetrahydrofolate.Biotechnology and Bioengineering. 2020, 117: 2116-2130.

66.Yaokang Wu, Yanfeng Liu, Xueqin Lv, Jianghua Li, Guocheng Du, Long Liu. CAMERS-B: CRISPR/Cpf1 assisted multiple-genes editing and regulation system forBacillus subtilis.Biotechnologyand Bioengineering. 2020, 117(6): 1817-1825.

67.Xueqin Lv, Ke Jin, Yaokang Wu, Cheng Zhang, Shixiu Cui, Xiaonan Zhu, Jianghua Li, Guocheng Du, Long Liu. Enzyme assembly guided by SPFH-induced functional inclusion bodies for enhanced cascade biocatalysis.Biotechnology and Bioengineering.2020, 117(5): 1446-1457. 4.002

68.Tengfei Niu, Xueqin Lv, Yanfeng Liu, Jianghua Li, Guocheng Du, Rodrigo Ledesma-Amaro, Long Liu. The elucidation of phosphosugar stress response inBacillus subtilisguides strain engineering for high N-acetylglucosamine production.Biotechnology and Bioengineering. 2020; 1-14.

69.Hao Huang, Qixing Liang, Yang Wang, Jian Chen, Zhen Kang. High-level constitutive expression of leech hyaluronidase with combined strategies in recombinantPichia pastoris.Applied Microbiology and Biotechnology. 2020, 104(4): 1621-1632.

70.Panhong Yuan, Shixiu Cui, Yanfeng Liu, Jianghua Li, Guocheng Du, Long Liu. Metabolic engineering for the production of fat-soluble vitamins: advances and perspectives.Applied Microbiology and Biotechnology.2020, 104(3): 935-951.

71.Yanfeng Liu, Anqi Su, Jianghua Li, Rodrigo Ledesma-Amaro, Peng Xu, Guocheng Du, Long Liu. Towards next-generation model microorganism chassis for biomanufacturing.Applied Microbiology and Biotechnology.2020, 104: 9095-9108.

72.Li Sun, Mengyue Gong, Xueqin Lv, Ziyang Huang, Yang Gu, Jianghua Li, Guocheng Du, Long Liu. Current advance in biological production of short-chain organic acid.Applied Microbiology and Biotechnology. 2020, 104: 9109-9124.

73.Panhong Yuan, Shixiu Cui, Yanfeng Liu, Jianghua Li, Xueqin Lv, Long Liu, Guocheng Du. Combinatorial engineering for improved menaquinone-4 biosynthesis inBacillus subtilis.Enzyme and Microbial Technology. 2020, 141: 109652.

74.Hao Wang, Lin Zhang, Yang Wang, Jianghua Li, Guocheng Du, Zhen Kang. Engineering the heparin-binding pocket to enhance the catalytic efficiency of a thermostable heparinase III fromBacteroides thetaiotaomicron.Enzyme and Microbial Technology. 2020, 137: 109549.

75.Liuyan Gu, Haibo Yuan, Xueqin Lv, Guangsheng Li, Rigang Cong, Jianghua Li, Guocheng Du, Long Liu. High-yield and plasmid-free biocatalytic production of 5-methylpyrazine-2-carboxylic acid by combinatorial genetic elements engineering and genome engineering ofEscherichia coli.Enzyme and Microbial Technology. 2020, 134: 109488.

76.Xueqin Lv, Shixiu Cui, Yang Gu, Jianghua Li, Guocheng Du, Long Liu. Enzyme Assembly for Compartmentalized Metabolic Flux Control.Metabolites.2020, 10(4): 125.

77.Fan Yang, Qiaoling Zhang, Yanfeng Liu, Jianghua Li, Li Wang, Jian Chen. Lactic acid biosynthesis pathways and important genes ofLactobacillus panisL7 isolated from the Chinese liquor brewing microbiome.Food Bioscience. 2020, 36: 100627.

78.Yexu Wu, Yanfeng Liu, Chuanchuan Lu, Senlin Lei, Jianghua Li, Guocheng Du. Quantitation of RNA by a fluorometric method using the SYTO RNASelect stain.Analytical Biochemistry.2020, 113857.

79.Chunmei Chen, Jieying Deng, Xueqin Lv, Jianghua Li, Guocheng Du, Huazhong Li, Long Liu. Biocatalytic synthesis of lactosucrose using a recombinant thermostable β-fructofuranosidase fromArthrobactersp. 10138.Bioengineered.2020, 11(1): 416-427.

80.Taichi Chen, Hongzhi Xia, Shixiu Cui, Xueqin Lv, Xueliang Li, Yanfeng Liu, Jianghua Li, Guocheng Du, Long Liu. Combinatorial Methylerythritol Phosphate Pathway Engineering and Process Optimization for Increased Menaquinone-7 Synthesis inBacillus subtilis.Journal of Microbiology and Biotechnology. 2020, 30(5): ‏762-769.

81.Chuanchuan Lu, Yanfeng Liu, Jianghua Li, Long Liu, Guocheng Du. Engineering of biosynthesis pathway and NADPH supply for improved L-5-methyltetrahydrofolate production byLactococcus lactis.Journal of Microbiology and Biotechnology. 2020, 606: 113857.

82.Ke Liu, Mengyue Gong, Xueqin Lv, Jianghua Li, Guocheng Du, Long Liu. Biotransformation and chiral resolution of d,l-alanine into pyruvate andd-alanine with a whole-cell biocatalyst expressingl-amino acid deaminase.Biotechnology and Applied Biochemistry.2020, 67(4):‏668-676.

83.Tengfei Niu, Xueqin Lv, Zhenmin Liu, Jianghua Li, Guocheng Du, Long Liu. Synergetic engineering of central carbon and nitrogen metabolism for the production of N-acetylglucosamine inBacillus subtilis.Biotechnology and Applied Biochemistry. 2020, 11(1): 416-427.

84.Angela Lombardi,Lionel Cheruzel,Long Liu. Synthetic and engineered enzymes for biocatalysis and biotransformation.BiotechnologyandApplied Biochemistry. 2020, 67: 4.

85.Xiaolong Zhang, Yanting Cao, Yanfeng Liu, Long Liu, Jianghua Li, Guocheng Du, Jian Chen. Development and optimization of N-acetylneuraminic acid biosensors inBacillus subtilis.Biotechnology andApplied Biochemistry.2020, 67(4): 693-705.

86.Chen Deng, Xueqin Lv, Jianghua Li, Yanfeng Liu, Guocheng Du, Long Liu. Development of a DNA double-strand break-free base editing tool inCorynebacterium glutamicumfor genome editing and metabolic engineering.Metabolic Engineering Communications. 2020，11: e00135.

87.Tanatarov Dinmukhamed, Ziyang Huang, Yanfeng Liu, Xueqin Lv, Jianghua Li, Guocheng Du, Long Liu. Current advances in design and engineering strategies of industrial enzymes.Systems Microbiology and Biomanufacturing.

88.Jieying Deng, Xueqin Lv, Jianghua Li, Guocheng Du, Jian Chen, Long Liu. Recent advances and challenges in microbial production of human milk oligosaccharides.Systems Microbiology and Biomanufacturing.

89.Rongzhen Tian, Minghu Wang, Jintian Shi, Xiaolong Qin, Haoyu Guo, Xuanjie Jia, Jianghua Li, Long Liu, Guocheng Du, Jian Chen, Yanfeng Liu. Cell-free synthesis system-assisted pathway bottleneck diagnosis and engineering inBacillus subtilis.Synthetic and Systems Biotechnology. 2020, 5: 131-136.

90.Yanfeng Liu, Anqi Su, rongzhen Tian, Jianghua Li, long Liu, Guocheng Du. Developing rapid growingBacillus subtilisfor improved biochemical and recombinant protein production.Metabolic Engineering Communications. 2020, 11: 00141.

91.张维娇,金学荣,徐雅晴,李江华,堵国成,康振.枯草芽孢杆菌表达与调控工具相关研究进展.《生物技术通报》. 2020, 4: 26-33.

92.牛腾飞,李江华,堵国成,刘龙,陈坚.微生物法合成N-乙酰氨基葡萄糖及其衍生物的研究进展.《食品与发酵工业》.2020, 1: 274-279.

方向四：

93.Chang Su, Jinsong Gong, Jiufu Qin, Jimeng He, Zhengchuan Zhou, Min Jiang, Zhenghong Xu, Jinsong Shi. Glutathione enables full utilization of wool wastes for keratin production and wastewater decolorization.Journal of Cleaner Production. 2020, 270: 122092.

94.Cheng Li, Li Wang, Zhengxing Chen, Yongfu Li, Juan Li. Facile and green preparation of diverse arabinoxylan hydrogels from wheat bran by combining subcritical water and enzymatic crosslinking.Carbohydrate Polymers.2020, 241, 116317.

95.Ren Wang, Hao Zhang, Zhengxing Chen, Qixin Zhong. Structural basis for the low digestibility of starches recrystallized from side chains of amylopectin modified by amylosucrase to different chain length.Carbohydrate Polymers. 2020, 241, 116352.

96.Jian He, Ren Wang, Wei Feng, Zhengxing Chen, Tao Wang. Design of novel edible hydrocolloids by structural interplays between wheat gluten proteins and soy protein isolates.Food Hydrocolloids. 2020, 100, 105395.

97.Qiong Wang, Mengmeng Xu, Liting Zhao, Feng Wang, Youran Li, Guiyang Shi, Zhongyang Ding. Transcriptome dynamics and metabolite analysis revealed the candidate genes and regulatory mechanism of ganoderic acid biosynthesis during liquid superficial-static culture ofGanoderma lucidum.Microbial Biotechnology. 2020, doi:10.1111/1751-7915.13670.

98.Xingqiao Peng, Li Zhu, Zhihai Wang, Xiaobei Zhan. Enhanced stability of the bactericidal activity of nisin through conjugation with gellan gum.International Journal of Biological Macromolecules. 2020, 148, 525-532.

99.Yanli Lei, Miaosen Wu, Junyi Wang, Hongtao Zhang, Xiaobei Zhan, Zhenglong Sun, Jianrong Wu. Preparation and property of a biantenna macromolecule based on polysialic acid.International Journal of Biological Macromolecules. 2020, 155, 1342-1349.

100.Xingqiao Peng, Li Zhu, Jiayun Guo, Zhenglong Sun, Mingming Zhao, Xiaobei Zhan. Enhancing biocompatibility and neuronal anti-inflammatory activity of polymyxin B through conjugation with gellan gum.International Journal of Biological Macromolecules. 2020, 147, 734-740.

101.Xingqiao Peng, Xingyue Yan, Li Zhu, Yiran Gu, Zhenglong Sun, Xiaobei Zhan. Preparation of polymyxin B-loaded gellan-polylysine polyion complex fibers with high affinity to endotoxin.International Journal of Biological Macromolecules. 2020, 160, 703-710.

102.Jinpeng Ye, Jinsong Gong, Chang Su, Yange Liu, Jinsong Shi. Fabrication and characterization of high molecular keratin based nanofibrous membranes for wound healing.Colloids and surfaces B: Biointerfaces. 2020, 194: 111-158.

103.Chao Chen, Ting Li, Zhengxing Chen, Li Wang, Xiaohu Luo. Absorption Rates and Mechanisms of Avenanthramides in a Caco-2 Cell Model and Their Antioxidant Activity during Absorption.Journal of Agricultural and Food Chemistry. 2020, 68, 2347-2356.

104.Hao Zhang, Ren Wang, Zhengxing Chen, Qixin Zhong. Amylopectin-Sodium Palmitate Complexes as Sustainable Nanohydrogels with Tunable Size and Fractal Dimensions.Journal of Agricultural and Food Chemistry. 2020, 68, 3796-3805.

105.Qi Zhang, Liting Zhao, YouRan Li, Feng Wang, Song Li, Guiyang Shi, Zhongyang Ding. Comparative transcriptomics and transcriptional regulation analysis of enhanced laccase production induced by co-culture ofPleurotus eryngiivar. ferulae withRhodotorula mucilaginosa.Applied Microbiology and Biotechnology. 2020, 104, 241-255.

106.Rongxian Zhang, Jinsong Gong, Chang Su, Jiufu Qin, Heng Li, Hui Li, Jinsong Shi, Zhenghong Xu. Recombinant expression and molecular engineering of the keratinase fromBrevibacillus parabrevisfor dehairing performance.Journal of Biotechnology. 2020, 320: 57.

107.Zhitao Li, Li Zhu, Wenlong Zhang, Xiaobei Zhan, Minjie Gao. New dynamic digestion model reactor that mimics gastrointestinal function.Biochemical Engineering Journal. 2020, 154, 107431.

108.Jinsong Gong, Jinpeng Ye, Liyan Tao, Chang Su, Jinsong Shi. Efficient keratinase expression via promoter engineering strategies for degradation of feather wastes.Enzyme and Microbial Technology. 2020, 137: 109550.

109.Chang Su, Jinsong Gong, Jinpeng Ye, Jimeng He, Ruiyi Li, Min Jiang, Yan Geng, Yan Zhang, Jinghua Chen, Zhenghong Xu, Jinsong Shi. Enzymatic extraction of bioactive and self-assembling wool keratin for biomedical applications.Macromolecular Bioscience. 2020, 20(9): 200007.

110.Yanan Li, Ren Wang, Zhengxing Chen, Xiuping Zhao, Xiaohu Luo, Li Wang, Yongfu Li, Fei Teng. Preparation of magnetic mesoporous silica from rice husk for aflatoxin B1 removal: Optimum process and adsorption mechanism.Plos One. 2020, doi: org/10.1371/journal.pone.0238837.

111.Minjie Gao, Liping Liu, Shan Li, Jiliang Lyu, Yun Jiang, Li Zhu, Xiaobei Zhan, Zhi-Yong Zheng. Multi-stage glucose/pachymaran co-feeding enhanced endo-β-1,3-glucanase production byTrichoderma harzianumvia simultaneous increases in cell concentration and inductive effect.Bioprocess and Biosystems Engineering. 2020, 43, 1479-1486.

112.Shunzhi Wang, Zikai Wang, Jinsong Gong, Jiufu Qin, Tingting Dong, Zhenghong Xu, Jinsong Shi. Improving the biocatalytic performance of co-immobilized cells harboring nitrilase via addition of silica and calcium carbonate.Bioprocess and Biosystems Engineering. 2020, 43: 2201.

113.Zhihong Du, Yulin Li, Xiaohu Luo, Jiali Xing, Qingchuan Zhang, Ren Wang, Li Wang, Zhengxing Chen. Effects of Electron Beam Irradiation on the Physicochemical Properties of Quinoa and Starch Microstructure.Starch-Starke. 2020, 72, 1900178.

114.Xiaopeng Xu, Zuoming Nie, Zhiyong Zheng, Li Zhu, Xiaobei Zhan. Effect of different nitrogen sources on the viscosity and rheological properties of welan gum produced bySphingomonassp. ATCC 31555.Journal of Texture Studies. 2020, 51: 642-649.

115.Xingqiao Peng, Gengliang Liu, Li Zhu, Kejing Yu, Kun Qian, Xiaobei Zhan. In vitro and in vivo study of novel antimicrobial gellan-polylysine polyion complex fibers as suture materials.Carbohydrate Research. 2020, 496, 108115.

116.王子凡,郑志永,高敏杰,李想,詹晓北.装配水平筛板的气升式反应器中气液传质特性的数值模拟.《过程工程学报》. 2020, 1: 20-26.

117.李想,陈瑜琦,王子凡,郑志永,陈海琴,高敏杰,詹晓北.螺旋筛板气升式反应器在真菌发酵中的应用.《食品与发酵工业》.202, 15: 93-99.

方向一：

1. Yi-Fan Huang, Kazuhiro Aoki, Sachiko Akase, Mayumi Ishihara, Yi-Shi Liu, Ganglong Yang, Yasuhiko Kizuka, Shuji Mizumoto, Michael Tiemeyer, Xiao-Dong Gao, Kiyoko F. Aoki-Kinoshita, Morihisa Fujita. Global mapping of glycosylation pathways in human-derived cells.Developmental Cell. 2021, 56, 1195-1209.

2. Haohan Chen, Youhe Xiang, Rongfeng Cai, Liang Zhang, Yuting Zhang, Nandi Zhou. An ultrasensitive biosensor for dual-specific DNA based on deposition of polyaniline on a self-assembled multi-functional DNA hexahedral-nanostructure.Biosensors and Bioelectronics. 2021, 179, 113066.

3. Rongfeng Cai, Shixin Zhang, Luo Chen, Maolin Li, Yuting Zhang, Nandi Zhou. Self-assembled DNA nanoflowers triggered by a DNA walker for highly sensitive electrochemical detection ofStaphylococcus aureus.ACS Applied Materials and Interfaces. 2021, 13, 4905-4914.

4. Rongfeng Cai, Zhongwen Zhang, Haohan Chen, Yaping Tian, Nandi Zhou. A versatile signal-on electrochemical biosensor forStaphylococcus aureusbased on triple-helix molecular switch.Sensors and Actuators: B. Chemical. 2021, 326, 128842.

5. Hui Yue, Jinri Chen, Xu Chen, Xiaoli Wang, Yuting Zhang, Nandi Zhou. Systematic screening and optimization of single-stranded DNA aptamer specific for N-acetylneuraminic acid: A comparative study.Sensors and Actuators: B. Chemical. 2021, 344, 130270.

6. Yi-Fan Huang, Shuji Mizumoto, Morihisa Fujita. Novel insight into glycosaminoglycan biosynthesis based on gene expression profiles.Frontiers in Cell and Developmental Biology. 2021, 9, 709018.

7. Fan Yin, Rongfeng Cai, Shuhua Gui, Yuting Zhang, Xiaoli Wang, Nandi Zhou. A portable and quantitative detection of microRNA-21 based on cascade enzymatic reactions with dual signal outputs.Talanta. 2021, 235,122802.

8. Si-Si Liu, Yi-Shi Liu, Xin-Yu Guo, Yoshiko Murakami, Ganglong Yang, Xiao-Dong Gao, Taroh Kinoshita, Morihisa Fujita. A knockout cell library of GPI biosynthetic genes

for functional studies of GPI-anchored proteins.Communications Biology. 2021, 4: 777.

9. Xin Jin, Luo Chen, Yuting Zhang, Xiaoli Wang, Nandi Zhou. A lateral flow strip for on-site detection of tobramycin based on dual-functional platinumdecorated gold nanoparticles.Analyst. 2021, 146, 3608.

10. Si-Si Liu, Fei Jin, Yi-Shi Liu, Yoshiko Murakami, Yukihiko Sugita, Takayuki Kato, Xiao-Dong Gao, Taroh Kinoshita, Motoyuki Hattori, Morihisa Fujita. Functional analysis of the GPI transamidase complex by screening for amino acid mutations in each subunit.Molecules.2021, 26, 5462.

11. Xin-Yu Guo, Xiao-Dong Gao, Morihisa Fujita. Sulfation of a FLAG tag mediated by SLC35B2 and TPST2 affects antibody recognition. Plos One. 2021, 16(5): e0250805.

12. Si-Si Liu, Fei Jin, Yi-Shi Liu, Yoshiko Murakami, Yukihiko Sugita, Takayuki Kato, Xiao-Dong Gao, Taroh Kinoshita, Motoyuki Hattori, Morihisa Fujita. Functional Analysis of the GPI Transamidase Complex by Screening for Amino Acid Mutations in Each Subunit.Molecules. 2021, 26(18): 5462.

13. Ya Jing ng, Tetsuya Hirata, Yi-Shi Liu, Xin-Yu Guo, Xiao-Dong Gao, Taroh Kinoshita, Morihisa Fujita. Human SND2 mediates ER targeting of GPI-anchored proteins with low hydrophobic GPI attachment signals.FEBS LETTERS. 2021, 595: 1542-155.

14. Ji-Xiong Leng, Wei-Wei Ren, Yuqing Li, Ganglong Yang, Xiao-Dong Gao, Morihisa Fujita. Cell engineering for the production of hybrid-type N-glycans in HEK293 cells.Journal of Biochemistry. 2021,170(1):139-151.

15. Yi-Shi Liu, Emmanuel Matabaro, Xiao-Dong Gao, Morihisa Fujita. Selecting cells expressing high levels of recombinant proteins using the GPI-anchored protein with selenocysteine system.Journal of Bioscience and Bioengineering.2021, 131(3): 225-233.

16. Aimin Li, Jia Liu, Fangli Ding, Xiaolei Wu, Cong Pan, Qing Wang, Ming Gao, Shenglin Duan, Xiaofeng Han, Kai Xia, Shiwei Liu, Yimin Wu, Zhiqiao Zhou, Xi Zhang, Xiao-Dong Gao. Maca extracts regulate glucose and lipid metabolism in insulin-resistant HepG2 cells via the PI3K/AKT signalling pathway.Food Science & Nutrition. 2021, 9: 2894-2907.

17. Jinyan Gao, Rongfeng Cai, Nandi Zhou. Development of a sensitive and stable chemiluminescent immunoassay for detection of birch pollen allergic specific IgE based on recombinant Bet v1 protein.Journal of Immunological Methods. 2021, 493: 113040.

方向二：

18. Liang Gong, Yanchun Li, Kaisa Cui, Ying Chen, Haofei Hong, Jiuming Li, Dan Li, Yuan Yin, Zhimeng Wu, Zhaohui Huang. Nanobody-engineered natural killer cell conjugates for

solid tumor adoptive immunotherapy.Small. 2021, 2103463.

19. Liushen Lu, Yan Zhang, Zhenbo Yuan, Jinyu Xu, Min Li, Yawen Wu, Lijun Wang, Shuping Huang, Yijian Rao. Easily fabricated HARCP/HAp photocatalyst for efficient and fast removal of tetracycline under natural sunlight.Chemical Engineering Journal. 2021, 412, 128620.

20. Yawen Wu, Liushen Lu, Yan Zhang, Zhenbo Yuan, Lifeng Yang, Lijun Wang, Yijian Rao. A bioinspired cercosporin/polymethylmethacrylate photocatalyst with high efficiency for decontamination of pharmaceuticals and pathogens.Journal of Hazardous Materials. 2021, 419, 126555.

21. Haofei Hong, Chen Li, Liang Gong, Jinfeng Wang, Dan Li, Jie Shi, Zhifang Zhou, Zhaohui Huang, Zhimeng Wu. Universal endogenous antibody recruiting nanobodies capable of triggering immune effectors for targeted cancer immunotherapy.Chemical Science. 2021, 12, 4623-4630.

22. Zijing Du, Yong Mao, Pengfei Zhang, Jing Hu,Junjie Fu, Qingjun You, Jian Yin. TPGS-galactose-modified polydopamine Co-delivery nanoparticles of nitric oxide donor and doxorubicin for targeted chemo-photothermal therapy against drug-resistant Hepatocellular

Carcinoma.ACS Applied Materials and Interfaces. 2021, 13(30): 35518-35532.

23. Huijie Zhang, Airan Ding, Baoting Ye, Zhiqing Wang, Jiawen Zhang, Lipeng Qiu, Jinghua Chen. Carbon nitride nanosheets for imaging rraceable CpG oligodeoxynucleotide delivery.ACS Applied Nano Materials. 2021, 4, 8546-8555.

24. Min Li, Jia Li, Baodang Guo, Xuanzhong Liu, Zhenbo Yuan, Yawen Wu, Huimin Yin, Shuping Huang, Yan Zhang, Yijian Rao. Discovery and characterization of a novel perylenephotoreductant for the activation of aryl halides.Journal of Catalysis. 2021, 399: 111-120.

25. Xiaoli Wang, Yufei Ye, Zhaohui Huang, Peter H. Seeberger, Jing Hu, Jian Yin. In vivo dual fluorescence imaging of mucin 1 and its glycoform in tumor cells.Nanoscale. 2021, 13, 15067.

26. Shijie Dai, Haofei Hong, Kun Zhou, Kai Zhao, Yuntian Xie, Chen Li, Jie Shi, Zhifang Zhou, Lei Nie, Zhimeng Wu. Exendin 4-hapten conjugate capable of binding with endogenous

antibodies for peptide half-life extension and exerting long-acting hypoglycemic activity.Jounal of Medicinal Chemistry. 2021, 64(8): 4947-4959.

27. Juan Zhou, Yanzhe Wu, Xihe Zhang, Jiahui Lai, Yuanli Li, Jian Xing, Liping Teng, Jinghua Chen. Enzyme catalyzed hydrogel as versatile bioadhesive for tissue wound hemostasis, bonding, and continuous repair.Biomacromolecules. 2021, 22(4): 1346-1356.

28. Zhi Cai, Yishu Yan, Juan Zhou, Yang Yang, Yan Zhang, Jinghua Chen. Multifunctionalized brush-like glycopolymers with high affinity to P‑selectin and antitumor metastasis activity.Biomacromolecules. 2021, 22(3): 1177-1185.

29. Xiaotao Wu, Mingzhu Kang, Danhui Wang, Min Zhu, Yiwei Hu, Yan Zhang, Chao Deng, Jinghua Chen, Liping Teng. Heparan sulfate analogues regulate tumor-derived exosome formation that attenuates exosome functions in tumor processes.International Journal of Biological Macromolecules.2021, 187(30): 481-491.

30. Shengtao Wang, Anhe Wang, Yuqi Ma, Qingquan Han,Yang Chen, Xin Li, Songyuan Wu, Jieling Li, Shuo Bai , Jian Yin. In situ synthesis of superorganism-like Au NPs within microgels with ultra-wide absorption in visible and near-infrared regions for combined cancer therapy.Biomaterials Science. 2021, 9, 774-779.

31. Han Lin, Haofei Hong, Lipeng Feng, Jie Shi, Zhifang Zhou, Zhimeng Wu. Synthesis of DNP-modified GM3-based anticancer vaccine and evaluation of its immunological activities for cancer immunotherapy.Chinese Chemical Letters. 2021, 32(12): 4041-4044.

32. Huijie Zhang, Airan Ding, Baoting Ye, Zhiqing Wang, Jiawen Zhang, Lipeng Qiu, Jinghua Chen. Carbon nitride nanosheets for imaging traceable CpG oligodeoxynucleotide delivery.ACS Applied Nano Materials. 2021, 4(8): 8546-8555.

33. Tingan Zhou, Shiyu Yu, Yifan Hu, Yan Zhang, Yuechen Song, Jieyu Chu, Changmei Liu, Yijian Rao. Enhanced cercosporin production by co-culturingCercosporasp. JNU001 with leaf-spot-disease-related endophytic bacteria.Microbial Cell Factories. 2021, 20:100.

34. Han Cui, Qimeng Wang, Ye Zhang, Mihail Barboiu, Yan Zhang, Jinghua Chen. Double-network heparin dynamic hydrogels: Dynagels as anti-bacterial 3D cell culture scaffolds. Chemistry-A European Journal. 2021, 27(24): 7080-7084.

35. Jinlong Liu, Haofei Hong, Jie Shi, Yuntian Xie, Zhongkai Lu, Zhicheng Liu, Zhifang Zhou, Zehua Bian, Zhaohui Huang, Zhimeng Wu. Dinitrophenol-mediated modulation of an anti-PD-L1 VHH for Fc-dependent effector functions and prolonged serum half-life.European Journal of Pharmaceutical Sciences. 2021, 165, 105941.

36. Yan Zhang, Mingze Xia, Min Li, Qian Ping, Zhenbo Yuan, Xuanzhong Liu, Huimin Yin, Shuping Huang, Yijian Rao. Energy-transfer-mediated photocatalysis by a bioinspired organic

perylenephotosensitizer HiBRCP.Journal of Organic Chemistry. 2021, 86, 15284-15297.

37. Han Lin, Kun Zhou, Dan Li, Haofei Hong, Yuntian Xie, Liang Gong, Yu Shen, Zhifang Zhou, Jie Shi, Zhimeng Wu. Dinitrophenol-hyaluronan conjugates as multivalent antibody-recruiting glycopolymers for targeted cancer immunotherapy.ChemMedChem. 2021, 16, 2960-2968.

38. Chun-jun Qin, Hongli Hou, Meiru Ding, Yikuan QiI, Guang-zong Tian, Xiao-peng Zou, Jun-jie Fu, Jing Hu, Jian Yin. Chemical synthesis of a synthetically useful L-galactosaminuronic

acid building block.Chinese Journal of Natural Medicines.2021, 20(2): 1-7.

39. Liu, Jinlong; Hong, Haofei; Shi, Jie; Xie, Yuntian; Lu, Zhongkai; Liu, Zhicheng; Zhou, Zhifang; Bian, Zehua; Huang, Zhaohui; Wu, Zhimeng. Dinitrophenol-mediated modulation of an anti-PD-L1 VHH for Fc-dependent effector functions and prolonged serum half-life.European Journal of Pharmaceutical Sciences. 2021, 165, 105941.

40. Han Lin, Kun Zhou, Dan Li, Haofei Hong, Yuntian Xie, Liang Gong, Yu Shen, Zhifang Zhou, Jie Shi, Zhimeng Wu. Dinitrophenol-Hyaluronan Conjugates as Multivalent Antibody-Recruiting Glycopolymers for Targeted Cancer Immunotherapy.ChemMedChem. 2021, 16(19): 2960-2968.

41. Ye Zhang, Qimeng Wang, Ziyan Wang, Difei Zhang, Jieyu Gu, Kewei Ye, Dandan Su, Yan Zhang, Jinghua Chen, Mihail Barboiu. Strong, Self-Healing Gelatin Hydrogels Cross-Linked by Double Dynamic Covalent Chemistry.ChemPlusChem. 2021, 86(11): 1524-1529.

42. Guangyi Yang, Guodong Mei, Peng Shen, Haofei Hong, Zhimeng Wu. Rapid assembly of phosphate-bridged tetra-mannose by ionic liquid-supported oligosaccharide synthesis.Carbohydrate Research. 500 (2021) 108209.

方向三：

43. Ruirui Xu, Yang Wang, Hao Huang, Xuerong Jin, Jianghua Li, Guocheng Du, Zhen Kang. Closed-loop system driven by ADP phosphorylation from pyrophosphate affords equimolar transformation of ATP to 3'-phosphoadenosine-5'-phosphosulfate.ACS Catalysis. 2021, 11, 10405-10415.

44. Xuerong Jin, Weijiao Zhang, Yang Wang, Jingyu Sheng, Ruirui Xu, Jianghua Li, Guocheng Du, Zhen Kang. Biosynthesis of non-animal chondroitin sulfate from methanol using genetically engineeredPichia pastoris.Green Chemistry. 2021, 23, 4365.

45. Chen Deng, Xueqin Lv, Jianghua Li, Hongzhi Zhang, Yanfeng Liu, Guocheng Du, Rodrigo Ledesma Amaro, Long Liu. Synergistic improvement of N-acetylglucosamine production by engineering transcription factors and balancing redox cofactors.Metabolic Engineering. 2021, 67, 330-346.

46. Han Yang, Xiaolong Zhang, Yanfeng Liu, Long Liu, Jianghua Li, Guocheng Du, Jian Chen. Synthetic biology-driven microbial production of folates: Advances and perspectives.Bioresource Technology. 2021, 324, 24624.

47. Yameng Xu, Yaokang Wu, Xueqin Lv, Guoyun Sun, Hongzhi Zhang, Taichi Chen, Guocheng Du, Jianghua Li, Long Liu. Design and construction of novel biocatalyst for bioprocessing: Recent advances and future outlook.Bioresource Technology. 2021, 332, 125071.

48. Ziyang Huang, Xinzhu Mao, Xueqin Lv, Guoyun Sun, Hongzhi Zhang, Wei Lu, Yanfeng Liu, Jianghua Li, Guocheng Du, Long Liu. Engineering diacetylchitobiose deacetylase fromPyrococcus horikoshiitowards an efficient glucosamine production.Bioresource Technology. 2021, 334, 125241.

49. Xinzhu Mao, Ziyang Huang, Guoyun Sun, Hongzhi Zhang, Wei Lu, Yanfeng Liu, Xueqin Lv, Guocheng Du, Jianghua Li, Long Liu. High level production of diacetylchitobiose deacetylase by refactoring genetic elements and cellular metabolism.Bioresource Technology. 2021, 341, 125836.

50. Yanting Cao, Rongzhen Tian, Xueqin Lv, Jianghua Li, Long Liu, Guocheng Du, Jian Chen, Yanfeng Liu. Inducible population quality control of engineeredBacillus subtilisfor improved N-acetylneuraminic acid biosynthesis.ACS Synthetic Biology. 2021, 10, 2197-2209.

51. Meng Chai, Chen Deng, Qi Chen, Wei Lu, Yanfeng Liu, Jianghua Li, Guocheng Du, Xueqin Lv, Long Liu. Synthetic Biology Toolkits and Metabolic Engineering Applied inCorynebacterium glutamicumfor Biomanufacturing.ACS Synthetic Biology. 2021, 10, 3237-3250.

52. HaoWang, Lin Zhang, YangWang, Jianghua Li, Guocheng Du, Zhen Kang. Engineering a thermostable chondroitinase for production of specifically distributed low-molecular-weight chondroitin sulfate.Biotechnology Journal. 2021, 2000321.

53. Tengfei Niu, Xueqin Lv, Yanfeng Liu, Jianghua Li, Guocheng Du, Rodrigo Ledesma-Amaro, Long Liu. The elucidation of phosphosugar stress response inBacillus subtilisguides strain engineering for high N-acetylglucosamine production.Biotechnology and Bioengineering. 2021, 118: 383-396.

54. Wang, Hao; Zhang, Lin; Wang, Yang; Li, Jianghua; Du, Guocheng; Kang, Zhen. Engineering a thermostable chondroitinase for production of specifically distributed low-molecular-weight chondroitin sulfate.Biotechnology Journal. 2021, 2000321.

55. Ke Liu, Haoran Yu, Guoyun Sun, Yanfeng Liu, Jianghua Li, Guocheng Du, Xueqin Lv, Long Liu. Semi-rational design of L-amino acid deaminase for production of pyruvate and d-alanine byEscherichia coliwhole-cell biocatalyst.Amino Acids. 2021, 53(9): 1361-1371.

56. Chuanchuan Lu, Yanfeng Liu, Jianghua Li, Long Liu, Guocheng Du. Engineering of Biosynthesis Pathway and NADPH Supply for Improved L-5-Methyltetrahydrofolate Production byLactococcus lactis.Journal of Microbiology and Biotechnology. 2021, 31(1): 154-162.

57. Wei Zhang, Zhenmin Liu, Mengyue Gong, Nan Li, Xueqin Lv, Xiaomin Dong, Yanfeng Liu, Jianghua Li, Guocheng Du, Long Liu. Metabolic engineering ofEscherichia colifor the production of Lacto-N-neotetraose (LNnT).Systems Microbiology and Biomanufacturing. 2021, 1: 291-301.

方向四：

58. Mengmeng Xu, Song Zhu, Youran Li, Sha Xu, Guiyang Shi, Zhongyang Ding. Effect of selenium on mushroom growth and metabolism: A review.Trends in Food Science & Technology. 2021, 118(A): 328-340.

59. Minjie Gao, Ying Xu, Guoshuai Yang, Shuxia Jin, Xiuyu Hu, Yun Jiang, Li Zhu, Zhitao Li, Xiaobei Zhan. One-step production of functional branched oligoglucosides with coupled fermentation ofPichia pastorisGS115 andSclerotium rolfsiiWSH-G01.Bioresource Technology. 2021, 335, 125286.

60. Jianying Qian, Jinsong Gong, Zhenghong Xu, Jian Jin, Jinsong Shi. Significant improvement in conversion efficiency of isonicotinic acid by immobilization of cells via a novel microsphere preparation instrument.Bioresource Technology. 2021, 32, 124307.

61. Zhiyuan Yao, Jiufu Qin, Jinsong Gong, Yunhui Ye, Jianying Qian, Heng Li, Zhenghong Xu, Jinsong Shi. Versatile strategies for bioproduction of hyaluronic acid driven by synthetic biology.Carbohydrate Polymers. 2021, 264, 118015.

62. Jianrong Wu, Zelin Yang, Xuechen Yang, Xiaotian Chen, Hongtao Zhang, Xiaobei Zhan. Synthesis of branched β-1,3-glucan oligosaccharide with narrow degree of polymerization by fungi co-cultivation.Carbohydrate Polymers. 2021, 273, 118582.

63. Liting Zhao, Zhongbao Ma, Jian Yin, Guiyang Shi, Zhongyang Ding. Biological strategies for oligo/polysaccharide synthesis: biocatalyst and microbial cell factory.Carbohydrate Polymers. 2021, 258, 117695.

64. Ying Wan, Ren Wang, Wei Feng, Zhengxing Chen, Tao Wang. High internal phase Pickering emulsions stabilized by co-assembled rice proteins and carboxymethyl cellulose for food-grade 3D printing.Carbohydrate Polymers. 2021, 273, 118586.

65. Minjie Gao, Feiyang Duan, Liping Liu, Xiuyu Hu, Li Zhu, Yun Jiang, Xiaobei Zhan. An innovative strategy of recycling miscellaneous waste carbohydrates from high-fructose syrup production forPichia pastorisfermentation.Journal of Cleaner Production. 2021, 326, 129404.

66. Xinxia Zhang, Zhongyu Zuo, Wenjin Ma, Peibin Yu, Ting Li, Li Wang. Assemble behavior of ultrasound-induced quinoa protein nanoparticles and their roles on rheological properties and stability of high internal phase emulsions.Food Hydrocolloids. 2021, 117, 106748.

67. Hao Zhang, Shuo Qian, Zhiming Rao, Zhengxing Chen, Qixin Zhong, Ren Wang. Supermolecular structures of recrystallized starches with amylopectin side chains modified by amylosucrase to different chain lengths.Food Hydrocolloids. 2021, 119, 106830.

68. Ren Wang, Zhuoshi Li, Tianqi Zhang, Hao Zhang, Xing Zhou, Tao Wang, Wei Feng, PeiBin Yu. Impact of amylose content on the starch branch chain elongation catalyzed by amylosucrase fromNeisseria polysaccharea.Food Hydrocolloids. 2021, 111, 106395.

69. Peng Zhang, Jinsong Gong, Jiufu Qin, Hui Li, Haijuan Hou, Xiaomei Zhang, Zhenghong Xu, Jinsong Shi. Phospholipids (PLs) know-how: exploring and exploiting phospholipase D for its industrial dissemination.Critical Reviews in Biotechnology. 2021, 41(8): 1257-1278.

70. Zhi-tao Li, Guo-aoHu, Li Zhu, Zhi-chao Zhao, Yun Jiang, Min-jie Gao, Xiao-bei Zhan. In vitro digestion and fecal fermentation of highly resistant starch rice and its effect on the gut microbiota.Food Chemistry. 2021, 361, 130095.

71. Ting Li, Li Wang, Xinxia Zhang, Peibin Yu, Zhengxing Chen. Complexation of rice glutelin fibrils with cyanidin-3-O-glucoside at acidic condition: Thermal stability, binding mechanism and structural characterization.Food Chemistry. 2021, 363, 130367.

72. Wei Feng, Hao Zhang, Ren Wang, Xing Zhou, Tao Wang. Modifying the internal structures of steamed rice cakes by emulsifiers for promoted textural and sensory properties.Food Chemistry. 2021, 354, 129469.

73. Ren Wang, Tingting Wang, Wei Feng, Qichu Wang, Tao Wang. Rice proteins and cod proteins forming shared microstructures with enhanced functional and nutritional properties.Food Chemistry. 2021, 354, 129520.

74. Xinxia Zhang, Zhongyu Zuo, Peibin Yu, Ting Li, Min Guang, Zhengxing Chen, Li Wang. Rice peptide nanoparticle as a bifunctional food-grade Pickering stabilizer prepared by ultrasonication: Structural characteristics, antioxidant activity, and emulsifying properties.Food Chemistry. 2021, 343, 128545.

75. Ting Li, Li Wang, Han Geng, Xinxia Zhang, Zhengxing Chen. Formation, structural characteristics, foaming and emulsifying properties of rice glutelin fibrils.Food Chemistry. 2021, 354, 129554.

76. Qi Meng, ShiChen Chuai, Lei Chen, Lingling Wang, Guolin Cai, Jinsheng Mao, Zhenghua Gu, Guiyang Shi, Zhongyang Ding. Effect of surfactants on the production of polysaccharides fromSchizophyllum communethrough submerged fermentation.International Journal of Biological Macromolecules.2021, 192, 210-218.

77. Jianrong Wu, MiaosenWu, Hongtao Zhang, Xiaobei Zhan, Nian Wu. An Oligomannuronic acid-sialic acid conjugate capable of inhibiting Aβ42 aggregation and alleviating the inflammatory response of BV-2 microglia.International Journal of Molecular Sciences.2021, 22, 12338.

78. Qinglan Wu, Jue Wu, Mingfei Ren, Xinxia Zhang, Li Wang. Modification of insoluble dietary fiber from rice bran with dynamic high pressure microfluidization: Cd(II) adsorption capacity and behavior.Innovative Food Science & Emerging Technologies. 2021, 73, 102765.

79. Yanan Li, Yongfu Li, Zhengxing Chen, Lingjuan Bu, Feng Shi, Jinrong Huang. High-temperature air fluidization improves cooking and eating quality and storage stability of brown rice.Innovative Food Science & Emerging Technologies. 2021, 67, 102536.

80. Qi Zhang, Chang Yuan, Feng Wang, Sha Xu, Youran Li, Guiyang Shi, Zhongyang Ding. Roles of small subunits of laccase (ssPOXA3a/b) in laccase production byPleurotus eryngii var. ferulae.Journal of Agricultural Food and Chemistry.2021, 69, 13113-13124.

81. Jian He, Yucheng Zong, Ren Wang, Wei Feng, Zhengxing Chen, Tao Wang. Simultaneous refolding of wheat proteins and soy proteins forming novel antibiotic superstructures by carrying eugenol.Journal of Agricultural Food and Chemistry. 2021, 69, 7698-7708.

82. Qinglan Wu, Mingfei Ren, Xinxia Zhang, Cheng Li, Ting Li, Zhi Yang, Zhengxing Chen, Li Wang. Comparison of Cd(II) adsorption properties onto cellulose, hemicellulose and lignin extracted from rice bran.LWT. 2021, 144, 111230.

83. Jingjing Xu, Ruyue Wang, Hongtao Zhang, Jianrong Wu, Li Zhu, Xiaobei Zhan. In vitro assessment of prebiotic properties of oligosaccharides derived from four microbial polysaccharides.LWT. 2021, 147, 111544.

84. Huan Li, Huiting Yang, Jingjing Xu, Zexin Gao, Jianrong Wu, Li Zhu, Xiaobei Zhan. Novel amphiphilic carboxymethyl curdlan-based pH responsive micelles for curcumin delivery.LWT. 2021, 153,112419.

85. Mengmeng Xu, Song Zhu, Lingling Wang, Zhiyi Wei, Liting Zhao, Guiyang Shi, Zhongyang Ding. Influence of selenium biofortification on the growth and bioactive metabolites ofGanoderma lucidum.Foods. 2021, 10(8): 1860.

86. Yuheng Zhai, Jiali Xing, Xiaohu Luo, Hao Zhang, Kai Yang, Xingfeng Shao, Kaihe Chen, Yanan Li. Effects of Pectin on the Physicochemical Properties and Freeze-Thaw Stability of Waxy Rice Starch.Foods. 2021, 10: 2419.

87. Zhi-tao Li, Li Zhu, Guo-ao Hu, Zheng-long Sun, Xiao-bei Zhan, Min-jie Gao.Akkermansia muciniphilafermentation culture based on a novel bionic large intestine dynamic digestion model.Food Bioscience. 2021, 43, 101260.

88. Zheng-Qi Wang, Chen-Xi Zhu, An-Ran Dai, Lei Chen, Cui-Ping You, Bo-Bo Zhang. Chemical Characterization and Antioxidant Properties of Cell Wall Polysaccharides from Antrodia cinnamomea mycelia.Food Bioscience.2021, 41, 100932.

89. Jingjing Xu, Weibao Liu, Jianrong Wu, Wen Wang, Zhuoping Wang, Xun Yu, Hongtao Zhang, Li Zhu, Xiaobei Zhan. Metabolic profiles of oligosaccharides derived from four microbial polysaccharides by faecal inocula from type 2 diabetes patients.International Journal of Food Sciences and Nutrition. 2021, 72(8): 1083-1094.

90. Ting Li, Li Wang, Xinxia Zhang, Peibin Yu, Zhengxing Chen. Effect of ionic strength on assembly behaviors and rheological properties of rice glutelin based fibrils.Journal of Cereal Science. 2021, 100, 103224.

91. Zhitao Li, Guoao Hu, Li Zhu, Zhenglong Sun, Yun Jiang, Min-jie Gao, Xiaobei Zhan. Study of growth, metabolism, and morphology ofAkkermansia muciniphilawith an in vitro advanced bionic intestinal reactor.BMC Microbiology. 2021, 21: 61.