讲座题目：A Poisson-Nernst-Planck single ion channel model and its effective finite element solver

主讲人：Zhen Chao教授（美国西华盛顿大学）

讲座时间：2024年9月6日（周五）15:30-16:30

讲座地点：钱伟长楼201会议室

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理学院

2024年9月5日

讲座内容简介：A single ion channel is a membrane protein with an ion selectivity filter that allows only a single species of ions (such as potassium ions) to pass through in the “open” state. Its selectivity filter also naturally separates a solvent domain into an intracellular domain and an extracellular domain. Such biological and geometrical characteristics of a single ion channel are novelly adopted in the construction of a new kind of dielectric continuum ion channel model, called the Poisson-Nernst-Planck single ion channel (PNPSIC) model. In this talk, an effective PNPSIC finite element solver is then developed and implemented as a software package workable for a single ion channel with a three-dimensional X-ray crystallographic molecular structure and a mixture of multiple ionic species. Numerical results for a potassium channel confirm the convergence and efficiency of the PNPSIC finite element solver and demonstrate the high performance of the software package. Moreover, the PNPSIC model is applied to the calculation of electric current and validated by biophysical experimental data.

主讲人简介：Zhen Chao，美国西华盛顿大学教授，博士毕业于威斯康星大学密尔沃基分校，主要从事细胞离子通道模型的算法研究，和相关数值线性代数方面的研究工作，在包括JCP，JCC，SIAM J CONTROL OPTIM，JCAM等著名国际期刊发表论文20多篇。